Association Between Modifiable Risk Factors and Cognitive Function in Patients With Coronary Heart Disease
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 2,352
- 试验地点
- 1
研究概览
简要总结
This prospective observational study aims to investigate the association between risk factors and cognitive function in patients with coronary heart disease (CHD), and to explore the underlying mechanisms involving metabolic parameters and multimodal imaging features. A total of 2,352 participants will be enrolled from Beijing Anzhen Hospital, Capital Medical University, China. Eligible participants are adults (≥18 years) with confirmed CHD who undergo systematic neuropsychological assessment during hospitalization. Comprehensive assessments include cognitive function tests (MMSE, MoCA, BCAT, AD8), metabolic evaluations (fasting glucose, insulin, HbA1c, ceramides), coronary computed tomography angiography (CCTA), cardiac magnetic resonance (CMR), sleep respiratory monitoring, and frailty and psychological assessments.The primary outcome is cognitive impairment. The study will identify potential risk factors and provide insights into early identification and personalized intervention strategies for cognitive decline in CHD patients.This study is led by the National Clinical Research Center for Cardiovascular Diseases and invited to be carried out by several Chinese centers including Beijing Anzhen Hospital.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥ 18 years
- •Diagnosis of coronary heart disease (meeting at least one of the following):
- •Coronary angiography or coronary CTA showing ≥50% stenosis in ≥1 major coronary artery;
- •Established diagnosis of coronary heart disease with prior medical, interventional, or surgical treatment;
- •Objective evidence of myocardial ischemia or typical clinical symptoms
- •Completion of standardized neuropsychological assessment during hospitalization
- •Completion of metabolic marker evaluation (fasting glucose, insulin, HbA1c, etc.) and agreement to undergo relevant imaging and functional assessments
- •Provision of signed written informed consent
排除标准
- •Previously diagnosed dementia.
- •History of stroke, cerebral hemorrhage, or other central nervous system diseases known to cause cognitive impairment.
- •Severe psychiatric disorders (e.g., schizophrenia, bipolar disorder).
- •Pregnancy or breastfeeding.
研究组 & 干预措施
CHD Patients with Cognitive Assessment Cohort
研究者
Chenchen Tu
Chief Physician
Beijing Anzhen Hospital