Study on the effect and mechanism of Buyang Huanwu decoction combined with probiotics on ischemic stroke based on intestinal flora

Phase 1

Not yet recruiting

• Conditions: Ischemic stroke

• Registration Number: ITMCTR2000003159
• Lead Sponsor: The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. Patients with cerebral infarction confirmed by CT or MRI;
2. Aged 50-75 years;
3. Patients with a course of 15 days to 3 months;
4. Patients with first onset, stable vital signs, clear consciousness, and ability to cooperate with examination and treatment;
5. Patients with unilateral limb motor dysfunction;
6. Patients who voluntarily participated in the study and signed informed consent.

Exclusion Criteria

1. Patients with serious heart, lung, liver, kidney and other organ diseases and various malignant tumors;
2. Patients with allergy to traditional Chinese medicine;
3. Patients who are taking probiotics or prebiotic preparations and have used any antibiotics within one month;
4. Patients who are unable to complete the test or have poor compliance and cannot cooperate due to other reasons;
5. Patients who are participating in other research trials that affect the results of this study.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Detection of serum TMAO level;Detection of MMM-9 by Serial inflammatory factors in Serum;Detection of hs-CRP by Serial inflammatory factors in Serum;Modified Barthel Index;Detection of serum SCFAs level;Detection of IL-6 by Serial inflammatory factors in Serum;Intestinal flora detection;Detection of TNF-a by Serial inflammatory factors in Serum;Fugl- Meyer Motor Function Scale;