Association of SPARC levels with the severity of coronary artery lesion in type 2 diabetic patients with coronary heart disease
Not Applicable
- Conditions
- Health Condition 1: E115- Type 2 diabetes mellitus with circulatory complications
- Registration Number
- CTRI/2023/08/056941
- Lead Sponsor
- FATHER MULLER RESEARCH CENTER
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Above 18 years of age and either sex.
2. WHO diagnostic criteria of 1999 will be used for diagnosis of diabetes.
3.Diagnosis criteria of CAD
Exclusion Criteria
Post CABG and PCI cases, patients with severe liver and kidney dysfunction, hyperlipidemia, arthritis, previous previous history of myocardial infarction, post trauma and infection, cancer patients treated with chemo/radiation therapy.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method It is hypothesized that if we can reduce SPARC content during the onset of T2DM, risk of CAD could be delayed. This study identifies the possibility of SPARC as a new early biomarker for diagnosing CAD in diabetic patients. This study may enable better life in patients diagnosed with diabetes and to deliver improved outcomes for diabetic patients when combined with clinical diagnostics.Timepoint: 8 months
- Secondary Outcome Measures
Name Time Method In this study, the levels of serum SPARC & its association with the severity of coronary artery lesion in T2DM patients with CAD is assessed. QCA reports were also investigated by Gensini scoring to to explore quantitative analysis of coronary stenosis.Timepoint: 12 months