Intensive versus Conventional Therapy to Slow the Progression of Idiopathic Glomerular Diseases
- Conditions
- progression renal disease due to Idiopathic Glomerular DiseasesRenal and Urogenital - Kidney disease
- Registration Number
- ACTRN12610000034033
- Lead Sponsor
- ASL6 Spedali Riuniti Livorno
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 130
Patients with estimated GFR>30 mL/min/1.73 m2 (36-102 mL/min/1.73 m2), Patients included had a clinical diagnosis of idiopathic chronic glomerulonephritis with urine protein >1g/g creatinine, confirmed at least in two separate occasions.
Patients with membranous glomerulonephritis and minimal change disease were excluded because of the possibility of spontaneous remission and the unpredictable response of these patients to treatment. Patients with diabetes mellitus, renovascular or malignant hypertension, secondary glomerular disease, rapidly progressive glomerulonephritis, malignancies, myocardial infarction, or cerebrovascular accident within the 6 months preceding the study, congestive heart failure, hepatic dysfunction, serum potassium >5 mEq/l, eGFR<30 ml/min/1.73m2, and a history of intolerance to angiotensin converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers ( ARBs) . We excluded patients treated with steroids, nonsteroidal anti-inflammatory drugs, or immunosuppressive agents within 6 months preceeding the study and patients previously treated with these drugs and achieving long period of remission.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Effects on proteinuria ( urine albumin-to creatinine ratio)[3 years following randomisation]
- Secondary Outcome Measures
Name Time Method Effects on eGFR ( estimated glomerular filtration rate) Blood anlysis and calculated formula[3 years following randomisation]