Identifying the underlying mechanisms and consequences of the loss of nasal T cells in vital and frail older individuals
- Conditions
- respiratory infections in elderly10019815
- Registration Number
- NL-OMON54081
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 170
Age, frailty score and self-reported respiratory tract infections in previous
year, ability to provide informed consent
• Incompetence to provide informed consent
• Current smoker or >40 pack year history
• History of severe nose bleedings
• Diagnosed with asthma, COPD or chronic rhinosinusitis
• Use of inhalation corticosteroids or antibiotics in the past 6 weeks
• Current use of anti-coagulants (to prevent nosebleeds). Platelet inhibitors
like acetylsalicylzuur (Ascal) are allowed
• Respiratory tract infection or common cold in the past 2 weeks
• Immunocompromised individuals (with primary immune deficiency or secondary
immune deficiency)
• Life expectancy <28 days in the opinion of study physician
• Vaccination in the 2 months prior to study start
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Frequency of nasal CD8+ T cells in young adults and frail older adults.</p><br>
- Secondary Outcome Measures
Name Time Method