A randomized comparative study to assess the effect of intrathecal magnesium sulphate as an adjuvant to hyperbaric bupivacaine versus isobaric levobupivacaine on post operative analgesia in parturients undergoing elective caesarean section at SMS Medical college Jaipur

Spinal Anaesthesia with hyperbaric bupivacaine and isobaric levobupivacaine is the most preferred technique of Anaesthesia in parturient undergoing lower segment caesarean sections (LSCS) which provides effective pain relief during intra operative and early postoperative period along with avoiding the risks of general Anaesthesia. However, recent studies show us that about 50%–70% of patients complain of moderate to severe pain after LSCS indicating that postoperative pain remains poorly managed.

For this a total of 74 patients (n=74) undergoing elective caesarean section who satisfy the inclusion criteria will be randomly divided into two groups of 37 each (A and B). Group A patients will be receiving hyperbaric bupivacaine 0.5% plus magnesium sulphate (75 mg) and group B will be receiving isobaric levobupivacaine 0.5% plus magnesium sulphate (75 mg).

When patients arrive in the operating room (OR), intravenous cannula (IV cannula) will be secured and hemodynamic variables will be measured. After this, spinal Anaesthesia will be administered using hyperbaric bupivacaine 0.5% plus magnesium sulphate (75 mg) in group A and isobaric levobupivacaine 0.5% plus magnesium sulphate (75 mg) in group B. Surgery will start after the block reaches T6 sensory level (complete sensory block). Quantitative values of time of onset of sensory loss, time of onset of complete motor block, time taken for sensory regression and post operative analgesia will be recorded.