CT Iterative ReConstruction for Low-dose cardiopulmonary Evaluation: diagnosis of pulmonary infections in patients with febrile neutropenia - Circle Study
- Conditions
- Febrile neutropenianeutropenic fever100479541002146010024970
- Registration Number
- NL-OMON39846
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 68
- Patients >= 18 years
- Neutropenia due to chemotherapy given for haematological disease or conditioning regimen for autologous or allogenic stem cell transplantation. Neutropenia is defined as absolute neutrophil count < 0.5 x 109 cells/L or a count of < 1.0 x 109 cells/L with a predicted decrease to < 0.5 x 109 cells/L within 3 days
- Chest X-ray made in the diagnostic work up on day 1 on the radiology department
- Fever (temperature > 38.3°C once or >= 38.0 °C longer than 1 hour) not related to administration of blood products or medication
- Written informed consent
- Patients with a known focus of infection unrelated to the lower respiratory tract
- Patients with a history of probable or proven invasive mould infection without a clinically available normalized chest CT and who use antimycotics
- Previous participation in the study
- Concomitant participation in a study in which the subject is exposed to X-rays
- Chest X-ray made on ward (*bed-thorax*)
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameters are chest X-ray, ultra low-dose CT, HRCT and<br /><br>consensus diagnosis. The main endpoint is sensitivity of imaging test for a<br /><br>pulmonary focus of febrile neutropenia as established by consensus diagnosis.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary study parameters/endpoints are routinely obtained serum galactomannan<br /><br>test, bronchoalveolar lavage (BAL) and blood tests.</p><br>