Oat Phenolics Bioavailability
Not Applicable
Completed
- Conditions
- Healthy
- Interventions
- Dietary Supplement: refined grainDietary Supplement: Oat bran
- Registration Number
- NCT02574039
- Lead Sponsor
- University of Reading
- Brief Summary
A diet rich in whole grain is inversely associated with cardiovascular disease risk and this benefit could be partly attributed to the phenolic acid content of whole grains. The exact absorption, metabolism and excretion of whole grain phenolic acids, however, is not fully understood. In a small human intervention trial, the investigators will investigate to what extent phenolic acids from whole grain oats are absorbed, excreted in urine and how they are metabolised.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 7
Inclusion Criteria
- Males
- 25 to 65 years old
Exclusion Criteria
- Allergies to oats
- Parallel participation in another research project
- Having flu vaccination or antibiotics within 3 months of trial start
- Taking food supplements within 3 months of trial start
- Past or existing medical history of vascular disease, diabetes, hepatic, renal, gastrointestinal, haematological, neurological, thyroidal disease or cancer
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Control refined grain Refined grain product and 350ml skimmed milk Oat bran Oat bran 66g oat bran made up in 350ml skimmed milk
- Primary Outcome Measures
Name Time Method Change from baseline in phenolic acid metabolite excretion Baseline and 48 hours
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Food and Nutritional Sciences
🇬🇧Reading, Berkshire, United Kingdom