The effect of left breast radiotherapy on the heart.

Phase 2

Recruiting

• Conditions: Heart Failure.; Systolic (congestive) heart failure; I50.2

• Registration Number: IRCT20210822052256N2
• Lead Sponsor: Esfahan University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 4 April 2022

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 37

Inclusion Criteria

All patients with left breast cancer over the age of 18 that have undergone left breast radiation therapy at Omid Hospital
Have not received chemotherapy or just received the TC (taxane-cyclophosphamide) chemotherapy regimen

Exclusion Criteria

Patients under 18 years old
Patients with end stage or metastatic malignancy
Patients with two synchronous cancers
Patients with a history of heart failure with LVEF=50% or a history of valvular heart disease or advanced congenital heart disease or proven coronary artery disease
Patients with a history of chest radiation therapy
Pregnant patients with breast cancer
Patients receives or have received of anthracyclines and trastuzumab

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Heart mean dose in radiation therapy for left breast cancer. Timepoint: Before and 6 months after left breast radiotherapy. Method of measurement: Dose volume histogram.

Secondary Outcome Measures

Name	Time	Method
Troponin. Timepoint: Before and just after left breast radiotherapy. Method of measurement: Laboratory test.;Brain natriuretic peptide. Timepoint: Before and just after left breast radiotherapy. Method of measurement: Laboratory test.;Left ventricle ejection fraction. Timepoint: Before and just after left breast radiotherapy. Method of measurement: Echocardiography.;Global longitudinal strain. Timepoint: Before and just after left breast radiotherapy. Method of measurement: Echocardiography.