Cold Snare Polypectomy Versus. Endoscopic Mucosal Resection

Not Applicable

• Conditions: Colonic Polyp
• Interventions: Other: EMR; Other: CSP

• Registration Number: NCT02476747
• Lead Sponsor: Asan Medical Center

Brief Summary

The investigators will investigate the efficacy of EMR compared to CSP in treatment of small colon polp (6\~10mm).

One aim of this study was to investigate the necessity of EMR on resection of small colon polyp.

Detailed Description

With sized polyp from 6mm to less than 10mm, it has been classified by the previous studies as a "small polyp".

Their potential for advanced neoplasia is usually size-dependent, but some recent studies found that, even in diminutive and small polyps, the rate of advanced neoplasia is relatively high about 9%-10%.

The investigators will prospectively investigate postprocedural outcomes, such as retrieval rate, procedural time, overall complication rate (Intraprocedural bleeding, postprocedural bleeding, and perforation) in colonoscopic polypectomy of small polyp between CSP and EMR.

Study Timeline

• Status Verified: 2015-06
• Study Start: 2015-06
• Study First Submitted: 2015-06-17
• Study First Submitted QC: 2015-06-17
• Study First Posted: 2015-06-19
• Last Update Submitted: 2015-06-23
• Last Update Posted: 2015-06-24
• Primary Completion: 2015-09
• Study Completion: 2015-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 103

Inclusion Criteria

• All those over the age of 20 years who agree informed consent and who have at least one polyp of eligible size (6-10 mm)

Exclusion Criteria

• (1) patients taking anticoagulant therapy during the past 1 week of the procedure, (2) known coagulopathy, (3) history of liver cirrhosis, chronic kidney disease, malignancy, inflammatory bowel diseases or significant infectious disease, (4) American Society of Anesthesiology class III or more, and (5) pedunculated polyps and polyps with malignant feature.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Endoscopic mucosal resection	EMR	EMR will be performed in the way of drawing the lesion into the loop of the snare and resecting followed by saline injection to the its margin.
Cold snare polypectomy	CSP	CSP will be performed by closing the snare loop after positioning the open snare at the point of lesion.

Primary Outcome Measures

Name	Time	Method
complete resection rate (CRR)	Up to 2 months

Secondary Outcome Measures

Name	Time	Method
incidence of complications (Intraprocedural bleeding, postprocedural bleeding, and perforation)	Up to 2 months
necessity of hemostasis (due to Intraprocedural bleeding or postprocedural bleeding)	Up to 2 months
Polyp retrieval rate	Up to 2 months
hospitalization period	Up to 2 months

Trial Locations

Locations (1)

Asan Medical Center; 🇰🇷 Seoul, Korea, Republic of