PET imaging of the noradrenaline system in healthy volunteers - a pilot study

Completed

• Conditions: het betreft gezonde vrijwilligers; healthy volunteers

• Registration Number: NL-OMON48264
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 4

Inclusion Criteria

age between 50 and 80 years

Exclusion Criteria

- past or present developmental disorder or psychiatric disorder
- abnormal results on the MMSE (<27)
- (subjective) memory complaints
- presence of any contra-indication for PET scanning
- participation in PET study in the last 12 months
- use of any medication that acts on the noradrenaline system

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>30-min static data can be derived, after acquisition, from the 90-min dynamic<br /><br>data. Several values will be computed and statistically compared against each<br /><br>other: NET binding potentials (BP), standardized uptake values (SUV) and K<br /><br>values will be computed for each region of interest (LC and projection areas),<br /><br>which will then be used to compute ratios using appropriate reference tissue<br /><br>models. Outcomes from both scan durations can be statistically compared. A<br /><br>non-significant result will show that the 30-min data is as reliable as the<br /><br>90-min data.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable.</p><br>