Effect of noradrenaline on cerebral hemodynamics and oxygenation in Neuro-ICU patients - an observational study

Not Applicable

• Conditions: Aneurysmal subarachnoid hemorrhage (aSAH) and traumatic brain injury (TBI); Not Applicable; Subarachnoid haemorrhage, unspecified

• Registration Number: ISRCTN94347640
• Lead Sponsor: ational Institute of Mental Health and Neurosciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-12-06
• Last Update Posted: 21 December 2021
• Study Completion: 2022-03-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

1. Adult anterior circulation aneurysmal subarachnoid patients following surgical clipping/coiling and requiring a continuous infusion of noradrenaline in the NICU
2. Adult traumatic brain injury patients following surgery requiring a continuous infusion of noradrenaline in the NICU

Exclusion Criteria

1. Refusal to provide informed consent
2. Pregnant patients
3. Patients with a poor acoustic window on TCD
4. Patients with carotid atheroma
5. Patient with bradycardia and arrhythmia
6. Patients with contraindications to nor-adrenaline infusion, including pre-existing
acute renal failure (serum creatinine >2 mg/dl) and ischemia of the digits
7. Patients who underwent decompressive craniectomy
8. Patients receiving more than one vasopressor

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Middle cerebral artery (MCA) blood flow velocity and cerebral autoregulation measured using transcranial doppler at baseline, 10% increase and 20% increase in mean arterial blood pressure

Secondary Outcome Measures

Name	Time	Method
Regional frontal cerebral oxygenation measured using near infra-red spectroscopy (NIRS) at baseline, 10% increase and 20% increase in mean arterial blood pressure