PET imaging of the noradrenaline system in healthy volunteers - a pilot study

• Conditions: Pilot study: healthy volunteers only.

• Registration Number: NL-OMON21724
• Lead Sponsor: niversity Medical Center Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 4

Inclusion Criteria

Age = 50 years and < 80 years; willingness to cooperate and sign written informed consent.

Exclusion Criteria

Past or present developmental disorder or psychiatric disorder; abnormal results on the MMSE (<27); (subjective) memory complaints; presence of any contra-indication for PET scanning; participation in PET study in the last 12 months; use of any medication that acts on the NA system; absence of signed informed consent form.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
From both the 90-min dynamic data and the 30-min static data, several values will be computed. These include NET binding potentials (BP), standardized uptake values (SUV) and K values for each region of interest (LC and projection areas), which will then be used to compute ratios using appropriate reference tissue models

Secondary Outcome Measures

Name	Time	Method
ot applicable.