Effect of cocoa vs. cocoa components on cardiometabolic biomarkers - a randomized, double-blind, placebo-controlled intervention study

Not Applicable

Completed

• Conditions: I10; E78; I70; Essential (primary) hypertension; Disorders of lipoprotein metabolism and other lipidaemias; Atherosclerosis

• Registration Number: DRKS00022056
• Lead Sponsor: Hochschule Niederrhein, Fachbereich Oecotrophologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-06-26
• Study Completion: 2022-04-21
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

BMI: 18,5 – 29,9 kg/m2, non-smoker for at least 3 months, written informed consent

Exclusion Criteria

Hypertension, hypercholesterolemia, hypertriglyceridemia, diabetes mellitus, antihypertensiva, lipid-lowering drugs, other medications with influence on vascular markers or lipids, diseases of gastrointestinal tract, kidneys and heart, lymphedema, removal of the axillary lymph nodes, pleuris, paresis, tremor, spasm, venous or arterial vessel accesses and dialysis shunts, cardiac pacemaker, (planned) pregnancy, lactation, planned changes in lifestyle, regular intake of supplements which might affect vascular health and serum lipids

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pulse wave velocity, in fasting state before and after 4-wk-intervention

Secondary Outcome Measures

Name	Time	Method
Blood pressure, endothelin-1, serum lipids (total cholesterol, LDL-cholesterol, HDL-cholesterol, and triglycerides); in fasting state before and after 4-wk-intervention