ocalization of specialized intestinal metaplasia and the molecular alterations in Barrett's esophagus in a Japanese population: an analysis of biopsy samples based on the "Seattle" biopsy protocol
- Conditions
- Barrett's esophagus
- Registration Number
- JPRN-UMIN000017994
- Lead Sponsor
- Division of Gastroenterology, Hyogo College of Medicine
- Brief Summary
1. MSI and hypermethylation at RUNX3, MGMT, hMLH1, p16 and APC genes were associated with BE carcinogenesis, but only APC gene hypermethylation was an independent predictive marker of EAC (OR=24.4, p=0.01) in the multivariate logistic regression analysis. In addition, the incidence of the these biomarkers did not show a significant difference between the 0-3 o'clock and 6-9 o'clock areas. 2. SIM was more frequently identified in the 0-3 o'clock quadrant than in the 6-9 o'clock quadrant (p=0.08). 3. The Ki-67 index was higher in SIM than in the columnar-lined epithelium (CLE) without goblet cells (p<0.0001), and in both SIM and CLE with Das-1 reactivity than in those without (p=0.04 and p=0.06, respectively). 4. The Ki-67 index was relatively higher in the 0-3 o'clock quadrant than in the 6-9 o'clock quadrant in cases with Das-1 reactivity.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 30
Not provided
(1) Patients with a history of esophagectomy or gastrectomy (2) Patients having no application to the guidelines for gastroenterological endoscopy in patients undergoing antithrombotic treatment from Japan Gastroenterological Endoscopy Society (3) Patients who have determined by the physicians to have any reasons of unqualified
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method