Evaluation of the effect of Alfa lipoic acid, Vitamin E supplementation and their combination on long term complications in patients on hemodialysis, Shiraz, 2010
Phase 2
- Conditions
- End stage of renal disease (hemodialysis).Chronic renal failure
- Registration Number
- IRCT201103156072N1
- Lead Sponsor
- Shiraz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 96
Inclusion Criteria
age 20-60 years, hemodialysis, twice a week, undergoing maintenance hemodialysis for more than 1 year, no receiving antioxidant supplements such as VitE, VitC, or fish oil
Exclusion criteria: smoking, pregnancy, presence of acute inflammatory and infectious diseases, presence of liver or Rheumatic diseases (such as lupus,...), cardiac diseases, or cancer, use of anticoagulants or contraceptives thyroxin
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Hs-CRP. Timepoint: Before and 2 months after intervention. Method of measurement: ELISA kit.;Malon-dialdehide (MDA). Timepoint: Before and 2 months after intervention. Method of measurement: Spectrophotometry.;Interlukin-6 (IL6). Timepoint: Before and 2 months after intervention. Method of measurement: RIA.
- Secondary Outcome Measures
Name Time Method Insulin. Timepoint: Before and 2 months after intervention. Method of measurement: ELISA kit.;Lipid profile. Timepoint: Before and 2 months after intervention. Method of measurement: Auto analyser.;FBS. Timepoint: Before and 2 months after intervention. Method of measurement: Auto analyser.