Effects of alpha lipoic acid on ß- Thalassemia Major

Phase 3

Conditions: ß-thalassemia Major.
Beta thalassaemia

Registration Number: IRCT2017061714237N2

Lead Sponsor: Kermanshah University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 30

Inclusion Criteria

Age over 15 years

Exclusion Criteria

History of hepatitis B and C
heart failure and kidney failure
cancer
allergies
digestive problems disrupting drug intake
pregnancy
smoking
The use of shlaturi except Desphonac
following a particular diet

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Homocysteine (HCY). Timepoint: Week 0, Week 8, Week 11, Week 19. Method of measurement: µmol/L, ELIZA.;Lipoprotein-associated phospholipase A2 (Lp-PLA2). Timepoint: Week 0, Week 8, Week 11, Week 19. Method of measurement: nmol/mL, ELIZA.;Trimethylamine N-oxide (TMAO). Timepoint: Week 0, Week 8, Week 11, Week 19. Method of measurement: µmol/L, ELIZA.;Osteoprotegerin (OPG). Timepoint: Week 0, Week 8, Week 11, Week 19. Method of measurement: mg/dl, ELIZA.;Total antioxidant capacity. Timepoint: Week 0, Week 8, Week 11, Week 19. Method of measurement: nmol/ml, ELIZA.;Malondialdehyde. Timepoint: Week 0, Week 8, Week 11, Week 19. Method of measurement: nm/ml, Tiobarbitoric acid.;Serum Iron. Timepoint: Week 0, Week 8, Week 11, Week 19. Method of measurement: µmol/ml, photometric.;Ferritin. Timepoint: Week 0, Week 8, Week 11, Week 19. Method of measurement: ngram/ml, ELIAZ.;Transferrin. Timepoint: Week 0, Week 8, Week 11, Week 19. Method of measurement: µgram/ml, ELIZA.

Secondary Outcome Measures

Name	Time	Method
Serum Triacylglyceride. Timepoint: Week 0, Week 8, Week 11, Week 19. Method of measurement: mg/dl, Enzymatic.;Serum Cholesterol. Timepoint: Week 0, Week 8, Week 11, Week 19. Method of measurement: mg/dl, Enzymatic.;HDL-c. Timepoint: Week 0, Week 8, Week 11, Week 19. Method of measurement: mg/dl, Direct Enzymatic.;LDL-c. Timepoint: Week 0, Week 8, Week 11, Week 19. Method of measurement: mg/dl, FriedWald Formula.;Body Weight. Timepoint: Week 0, Week 8, Week 11, Week 19. Method of measurement: Scale, Kilogram.