The Attenuating Effect of Soluble Fiber Consumption on Postprandial Glycemia in Humans

Not Applicable

Completed

• Conditions: Type2 Diabetes; Blood Sugar; High; Postprandial Hyperglycemia
• Interventions: Other: Control; Other: Isomaltodextrin Low Dose; Other: Resistant Starch Type 4; Other: GPC partially digestible maltodextrin; Other: Isomaltodextrin High Dose

• Registration Number: NCT05349916
• Lead Sponsor: Purdue University

Brief Summary

The main objective of the current study is to investigate whether consumption of soluble fibers (isomaltodextrin \[IMD\], partially digestible maltodextrin) and RS4 starch will lower postprandial glycemia as well as postprandial insulin in human subjects with relatively high fasting blood glucose, when consumed with a specific amount of digestible carbohydrate (rice porridge). The primary outcome of the study is the effect of fibers on postprandial blood glucose, whereas the secondary outcome will be its effect on postprandial blood insulin.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-10-17
• Study Start: 2021-12-07
• Primary Completion: 2022-03-09
• Study Completion: 2022-03-09
• Status Verified: 2022-04
• Study First Submitted QC: 2022-04-22
• Last Update Submitted: 2022-04-22
• Study First Posted: 2022-04-27
• Last Update Posted: 2022-04-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• Body mass index (18.5 kg/m² ≤ BMI ≤ 29.9 kg/m²)
• No history of abnormal glucose metabolism
• No ongoing use of drugs affecting blood glucose levels
• Fasting blood glucose between 90-110 mg/dL
• Low dietary fiber intake (less than 15 g per day)

Exclusion Criteria

• Diabetic individuals
• Individuals with history of gastrointestinal disease
• Pregnant or nursing women

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Control	Control	-
Isomaltodextrin Low Dose	Isomaltodextrin Low Dose	-
Resistant Starch Type 4	Resistant Starch Type 4	-
GPC partially digestible maltodextrin	GPC partially digestible maltodextrin	-
Isomaltodextrin High Dose	Isomaltodextrin High Dose	-

Primary Outcome Measures

Name	Time	Method
Postprandial glycemic response	Acute study: [3 hours of measurement after consumption of test food]	Blood glucose will be measured, (t max)

Secondary Outcome Measures

Name	Time	Method
Postprandial insulin response	Acute study: [3 hours of measurement after consumption of test food]	Blood insulin will be measured, (t max)

Trial Locations

Locations (1)

Purdue University; 🇺🇸 West Lafayette, Indiana, United States