role of increased tendency of blood clotting in patients undergoing treatment for infertility
Not Applicable
- Conditions
- Health Condition 1: R791- Abnormal coagulation profile
- Registration Number
- CTRI/2023/03/050479
- Lead Sponsor
- Dr Mehtab Kaur
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1 Women aged < 40 years old
2 Failure of at least one cycle of Frozen Embryo transfer with good embryo quality (grade 1 and 2)
Exclusion Criteria
1 APLA positive status
2 Any structural causes- abnormal uterine cavity
or presence of myoma
3 Severe male factor infertility
4 Any contraindication to heparin therapy
5 Poor embryo quality (grade 3 or 4 )
6 Fresh embryo transfer/ first cycle of FET
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To Evaluate the role of TEG as a screening test for hypercoagulable/ thrombophilic state, necessitating the need for anticoagulationTimepoint: At baseline, before start of FET preparation day 21 of cycle
- Secondary Outcome Measures
Name Time Method Cost- effectiveness of adding Low Molecular Weight Heparin in TEG positive women on pregnancy outcomeTimepoint: from time of embryo transfer till 12 weeks of gestation;To assess the Uterine artery doppler velocimetry changes in patients with a positive thromboelastogram <br/ ><br> <br/ ><br>Timepoint: 1) assessed at first visit, on 21st day of cycle before start of FET preparation <br/ ><br>2) on day 2 of cycle before starting endometrial preparation <br/ ><br>