Effectiveness of Opioid Free Anesthesia Using Dexmedetomidine Inhibiting Nociception in Abdominal Laparoscopic Surgery
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 74
- 试验地点
- 1
- 主要终点
- Heart rate
研究概览
简要总结
Effectiveness of opioid free anesthesia using Dexmedetomidine to inhibit nociception in abdominal laparoscopic surgery
详细描述
Abdominal laparoscopic surgery is one of the most common procedures worldwide, commonly facilitated with opioid balanced anesthesia or regional anesthesia. Despite being a controversy, there are issues that suggest opioid to have an influence in tumor recurrence. The investigators performed general anesthesia without opioid in laparoscopic abdominal surgery, and compared the hemodynamic instability, total consumption of fentanyl rescue, qNOX score, Ephedrine intraoperative, and Numerical Rating Scale.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- •Allergy to dexmedetomidine
- •Heart rate < 60 or systolic blood pressure <100 mmHg
- •Severe cardiovascular, uncontrolled hypertension (stage 2) or hepatic or renal disorder
- •Pregnancy
- •Difficult airway
- •Drop out Criteria:
- •Intraoperative emergency
- •Convert to open laparatomy
- •Decided to withdraw from the study
研究组 & 干预措施
Opioid free anesthesia
Patients in this group are given a combination of Dexmedetomidine, Lidocaine, Propofol, Sevoflurane, Rocuronium for induction and maintenance of general anesthesia. They are given rescue analgesia (fentanyl) when required, and Ephedrine as needed.
Patients were monitored using standard ASA monitoring and Connox.
Post operative pain score was assessed with NRS
干预措施: Dexmedetomidine (Drug)
Opioid balanced anesthesia
Patients in this group are given a combination of Opioid (Fentanyl), Lidocaine, Propofol, Sevoflurane, Rocuronium for induction and maintenance of general anesthesia. They are given Ephedrine as needed.
Patients were monitored using standard ASA monitoring and Connox.
Post operative pain score was assessed with NRS
干预措施: Fentanyl (Drug)
结局指标
主要结局
Heart rate
时间窗: Intraoperative
Heart rate
Blood pressure
时间窗: Intraoperative
blood pressure, both systolic and diastolic measured with non invasive blood pressure monitoring
次要结局
- Total consumption of Opioid(Intraoperative)
- quantium nociception index (qNOX)(Intraoperative)
- Ephedrine(intraoperative)
- Pain score(24 hour)
研究者
Aida Rosita Tantri
Principal Investigator
Indonesia University