Skin antiseptic trial for insertion of central venous catheters in neonates

Not Applicable

Completed

• Conditions: Specialty: Children, Primary sub-specialty: Neonatal; Infections and Infestations; Catheter infection

• Registration Number: ISRCTN82571474
• Lead Sponsor: orfolk and Norwich University Hospitals NHS Foundation Trust

Brief Summary

2019 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/30782955 protocol 2023 Results article in https://pubmed.ncbi.nlm.nih.gov/37907266/ (added 01/11/2023)

Detailed Description

Not available

Study Timeline

• Study Start: 2016-07-14
• Study Completion: 2019-10-15
• Last Update Posted: 13 November 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 116

Inclusion Criteria

1. Preterm infants born at <34 weeks’ gestation
2. Requiring routine insertion of a PCVC for parenteral nutrition
3. No new suspected sepsis with commencement of antibiotics occurring within the 48 hours preceding planned catheter insertion
4. No other indwelling PCVC already in situ

Exclusion Criteria

1. No realistic prospect of survival in the short term
2. Life-threatening congenital abnormality
3. Underlying skin condition
4. Already has another indwelling PCVC in situ or was previously enrolled into the study in respect of an earlier PCVC episode
5. Positive blood culture (BC) within the past 7 days without a subsequent negative blood culture result
6. Antibiotic treatment commenced for suspected sepsis within the preceding 48 hours

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Proportion of babies in the 70%IPA/2%CHG arm with catheter colonisation as determined by culture of catheter segments taken at the time of catheter removal.