Comparison of the effectiveness of tranexamic acid drug in simultaneous intravenous and joint administration compared to only joint administration in reducing bleeding after knee joint replacement surgery.

Phase 3

Recruiting

• Conditions: Reduction of bleeding during knee replacement surgery among subjects receiving intravenous and intra-articular tranexamic acid and subjects receiving intra-articular only..; total knee replacement; 81.41

• Registration Number: IRCT20220222054093N1
• Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 21 November 2022

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Patients with severe knee osteoarthritis whose pain is not controlled by drug treatment and are candidates for joint replacement.

Exclusion Criteria

Patients who have contraindications to receive tranexamic acid

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Determination of efficacy and safety of intra-articular and intravenous TXA in primary TKA. Timepoint: The intravenous group receives 15 mg per kilogram of the patient's weight intravenously, 5 minutes before the tourniquet is inflated, and 5 minutes after the completion of the skin suture and before the opening of the tourniquet, the same intravenous dose is injected again. The local group receives only 15 mg of tranexamic acid per kilogram of the patient's weight after the completion of the skin suture and 5 minutes before opening the tourniquet. The amount of hemoglobin after the operation is measured at intervals of 6 hours, 12 hours, 24 hours and 48 hours. In addition, the need for blood transfusion is also checked. Method of measurement: Laboratory test.