NCT04971564招募中不适用
Thrombo-inflammation Biomarkers Trial in Acute Cerebral Hypoxia. A Case-control Trial Nested in a Cohort
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Biomarker rates at day 0
研究概览
简要总结
The goal of this trial is to study, in three well-defined clinical situations responsible for cerebral hypoxia, the concentrations of biomarkers of thrombo-inflammation compared to a population of patients without cerebral hypoxia, and to study in patients with cerebral hypoxia the association between these concentrations and the clinical evolution.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •- For cases, admitted within the first 36 hours of an acute neurological symptom related to :
- •An ischaemic cerebrovascular accident (iCVA) eligible for a mechanical thrombectomy procedure,
- •A subarachnoid haemorrhage (SAH, all aetiologies) : patient presenting with at least a modified Fisher scale 3 or 4,
- •An intra-parenchymal haematoma (IPH) with greatest axis ≥ 20mm or with NIHSS on admission >
- •For control patients, admitted within 7 days of the onset of acute neurological symptomatology related to a clinical diagnosis of transient ischaemic attack (TIA) - based on thorough questioning of the patient on admission - and prior to imaging, with an ABCD2≥ 2 score.
- •Express consent to participate in the study.
- •Member or beneficiary of a social security.
排除标准
- •Pre-existing functional and/or cognitive disability
- •Patient under legal protection.
- •Pregnant or breastfeeding woman.
- •Patient with secondary haemorrhagic transformation.
- •Secondary exclusion criteria :
- •Patients with an ischaemic lesion visible on imaging, unrelated to large vessel occlusion and therefore ineligible for mechanical thrombectomy.
- •Patients diagnosed with an acute non-vascular neurological pathology (migraine, epilepsy, etc.).
- •TIA patients presenting an abnormality on follow-up imaging 24-48 hours after the initial imaging.
- •Excluded patients will be replaced.
结局指标
主要结局
Biomarker rates at day 0
时间窗: 24 hours
Biomarker: Neutro-Plaket aggregates, extra-cellular DNA networks, von Willebrand Factor
次要结局
未报告次要终点
研究者
研究点 (1)
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