Influence of Eggs on Cognitive Performance
- Conditions
- Cognitive Function
- Interventions
- Other: Omega-3 eggsOther: egg yolkOther: egg whitesOther: whole eggs
- Registration Number
- NCT06465888
- Lead Sponsor
- Texas A&M University
- Brief Summary
This clinical trial aims to evaluate the nutrients in eggs in healthy adult's cognitive performance. The main questions it aims to answer are:
* How do the nutrients in eggs impact visual cognitive performance (VCP) in generally healthy older individuals?
* Will omega-3 fatty acids in eggs improve VCP in generally healthy older individuals?
Participants will be randomly placed in one of five dietary treatment groups, including four egg whites, two whole regular eggs, two whole omega-3 fortified eggs, four egg yolks, and a no-egg control. Blood will be drawn at baseline. During the first two weeks, participants will eat assigned eggs, consume their usual diet other than the eggs, and keep five food logs. Cognitive performance testing will start on day 15 and be measured over a 10-day period using the Neurotracker (NT) 3-D program. Data on ancillary factors influencing outcomes will be collected, and food will be logged on each NT training day. Blood will be drawn at the end of the study and compared with baseline levels.
- Detailed Description
Generally, healthy males or 2 years post-menopausal females between 50 and 75 years old will be recruited for this study. Potential subjects will communicate interest to researchers, and a standardized email with a consent form will be sent to persons of interest. Prospective participants will complete a preliminary questionnaire evaluating visual health and Mini Mental State Exam (MMSE) to confirm inclusion criteria met, a study ID will be assigned. subjects will be randomly placed in a control group or one of four intervention groups: four egg whites, two whole regular eggs, two whole omega-3 eggs, and four egg yolks. Eggs will be provided to subjects based on their treatment groups; egg distribution will occur on days 1 and 15. Fifteen days of food logs, five days during the first 14 days of the study, and ten days of food logs each day the subjects train on the Neurotracker software. Food logs will be analyzed using Nutribase software.
Two weeks after the commencement of the study (Day 15), cognitive performance testing will begin. This testing will be conducted over a 10-day period, consisting of 15 training sessions. The Neurotracker (NT) 3-D program will be used for these sessions. On each NT training day, a daily data questionnaire will be used to collect data on ancillary factors that may influence the outcomes of the study.
Blood will be drawn at baseline, on day 15, and at the end of the study. Average nutrient intake and dietary patterns, baseline plasma draws, rate of change, and maximal performance on the NT software will be examined.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 106
- Healthy men and post-menopausal women who are age 50 to 75 years
- Taking supplements with >6 mg L and/or >2 mg Z two months before the study
- Self-reported diagnosis of age-related macular degeneration, diabetic retinopathy, glaucoma, or other eye conditions that may negatively impact visual cognitive performance
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- FACTORIAL
- Arm && Interventions
Group Intervention Description Whole Omega-3 Egg Group Omega-3 eggs Participants will eat two Christopher Farms whole omega-3 eggs/day for 30 days. Participants will be given a specified number of Christopher Farm eggs that will last them until their next appointment. They will be asked to eat no other eggs than the two from the eggs given to them and to return cartons with any leftover eggs. Egg Yolk Group egg yolk Participants will eat four egg yolks/day for 30 days. Participants will be given a specified number of Kieke eggs to last them until their next appointment. They will be asked to eat no other eggs than the yolks from the eggs given to them and to return cartons with any leftover eggs. Egg White Group egg whites Participants will eat four egg whites/day for 30 days. Participants will be given a specified number of Kieke eggs to last them until their next appointment. They will be asked to eat no other eggs than whites from the eggs given to them and to return cartons with any leftover eggs. Whole Egg Group whole eggs Participants will eat two whole eggs/day for 30 days. Participants will be given a specified number of Kieke eggs to last them until their next appointment. They will be asked to eat no other eggs than the eggs given to them and to return cartons with any leftover eggs.
- Primary Outcome Measures
Name Time Method Cognitive performance 15 cognitive sessions within 10 days over 2 week period Neurotracker 3-Dimensional software used to measure cognitive performance
Nutrient Intake (Lutein and Zeaxanthin) Through study completion which may take up to 2 years. Serum will be drawn and analyzed for lutein and zeaxanthin content
- Secondary Outcome Measures
Name Time Method Serum Lipid Levels Through study completion which may take up to 2 years. Serum will be drawn and analyzed for lipoprotein subfractions
Trial Locations
- Locations (1)
Gilchrist Building
🇺🇸College Station, Texas, United States