Octreotide as Palliative Therapy for Cancer-Related Bowel Obstruction That Cannot Be Removed by Surgery

Phase 2

Completed

• Conditions: Ovarian Cancer; Pancreatic Cancer; Peritoneal Cavity Cancer; Colorectal Cancer; Gastric Cancer; Nausea and Vomiting; Small Intestine Cancer; Extrahepatic Bile Duct Cancer; Constipation, Impaction, and Bowel Obstruction; Gastrointestinal Stromal Tumor

• Registration Number: NCT00004895
• Lead Sponsor: Northwestern University

Brief Summary

RATIONALE: Palliative therapy with octreotide may help patients who have bowel obstruction that cannot be removed by surgery to live longer and more comfortably.

PURPOSE: Phase II trial to study the effectiveness of octreotide as palliative therapy in treating patients who have cancer-related bowel obstruction that cannot be removed by surgery.

Detailed Description

OBJECTIVES:

* Determine the effectiveness of octreotide in the palliation of bowel obstruction secondary to cancer.

* Characterize the dose and tolerability of octreotide in this patient population.

OUTLINE: Patients receive octreotide subcutaneously or IV over 24 hours on days 2-5.

Patients who respond well to study may continue octreotide for palliative effects.

PROJECTED ACCRUAL: A total of 9-25 patients will be accrued for this study over 9 months.

Study Timeline

• Study Start: 1999-10
• Study First Submitted: 2000-03-07
• Primary Completion: 2002-10
• Study Completion: 2002-10
• Study First Submitted QC: 2003-05-08
• Study First Posted: 2003-05-09
• Disposition First Submitted: 2011-02-16
• Disposition First Submitted QC: 2011-02-16
• Disposition First Posted: 2011-02-18
• Status Verified: 2012-05
• Last Update Submitted: 2012-05-31
• Last Update Posted: 2012-06-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Robert H. Lurie Comprehensive Cancer Center, Northwestern University; 🇺🇸 Chicago, Illinois, United States