Comparison of intravenous mode of administration of injection of drugs like lidocaine,esmolol and protofol for decreasing the cough and blood pressure and heart rate response while removing the endotracheal tube in patients who underwent off pump coronary artery bypass(heart) surgery
Not Applicable
Not yet recruiting
- Conditions
- Health Condition 1: I21- Acute myocardial infarctionHealth Condition 2: I248- Other forms of acute ischemic heart disease
- Registration Number
- CTRI/2021/03/032097
- Lead Sponsor
- anjappa S N PRIMARY INVESTIGATOR
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Elective OPCAB surgeries,EF > 50%
Airway Mallampati grading 1 and 2
Exclusion Criteria
On pump CABG
poor lv function (EF less than 50 %)
patients on iabp support
allergy to study drug
unwilling patients
difficult airway
Morbid obese (BMI > 35 kg/m2)
emergency surgery
AV Conduction block greater than first degree
SBP < 100 mmHg, DBP < 50 mmHg
HR < 60 beats per min
Bronchospasm or bronchial asthma/ COPD pts
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method attenuation of extubation response in OPCAB surgeriesTimepoint: Before administration of study drug,after admistration before extubation,1min,2min,3 min,5min,10minutes
- Secondary Outcome Measures
Name Time Method PREVENTION OF MYOCARDIAL ISCHEMIATimepoint: 0 MINUTES TO 2 HOUR
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms explain lidocaine's attenuation of cough and sympathomimetic responses during extubation in OPCAB patients?
How does esmolol compare to propofol in reducing hemodynamic surges post-OPCAB extubation in acute ischemic heart disease patients?
Which biomarkers correlate with differential efficacy of intravenous anesthetics in mitigating extubation-induced hypertension and tachycardia?
What are the potential adverse event profiles of lidocaine, esmolol, and propofol in post-cardiac surgery extubation protocols?
Are there synergistic effects of combining lidocaine with beta-blockers like esmolol for managing sympathomimetic responses after OPCAB surgery?