Ondansetron versus Acetaminophen for Prevention of Postspinal Anesthesia Shivering in Cesarean Section: A Randmized Controlled Trial
Phase 1
Recruiting
- Conditions
- Anaesthesia
- Registration Number
- PACTR202203547348725
- Lead Sponsor
- Anesthesia department
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Female
- Target Recruitment
- 90
Inclusion Criteria
ASA physical status II female patients,
18-40 years old
scheduled for caesarean section under spinal anesthesia.
Exclusion Criteria
fever or hypothermia before the procedure.
History of hypertension, cardiovascular, psychiatric, neurological, endocrine, chest disease, and/or severe renal or hepatic dysfunction .
obese patients (BMI =30 kg/m2)
those who will need intraoperative blood transfusion
those with known allergy to any of this study drugs.
Any contraindication to neuraxial block
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method occurrence of shivering<br>The shivering severity will be graded as: grade 1(piloerection or peripheral cyanosis, but without visible muscle activity), grade 2 (visible muscle activity confined to one muscle group), grade 3(visible muscle activity in more than one muscle group), or grade 4 (gross muscle activity involving the whole body).Any shivering attack with a score >2 will be treated with Meperidine 25 mg IV. Shivering will be analysed for incidence (number of attacks), severity, time to occur after the intrathecal anesthetic, and its response to meperidine administration.
- Secondary Outcome Measures
Name Time Method totally received meperidine doses, the time for first postoperative analgesia request, the occurrence of hypotention or bradycardia, the perioperative complications (nausea, vomiting, dry mouth, dizziness, and desaturation).