Repeated magnetic resonance imaging in esophageal cancer for adaptive radiation treatment planning during chemoradiotherapy.
- Conditions
- esophageal canceroesophageal carcinoma1001799010017991
- Registration Number
- NL-OMON46841
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 30
- Histologically confirmed squamous-cell carcinoma, adenocarcinoma or large-cell undifferentiated carcinoma of the esophagus or esophagogastric junction (i.e. tumors involving both cardia and esophagus on endoscopy) - For nCRT: potentially resectable tumor (cT1b-4b N0-3 M0) and undergoing preoperative chemoradiation according to CROSS-regimen - For dCRT: unresectable tumor (T4bNxM0) or medically unfit patient for surgery due to comorbidities based on multidisciplinary consensus, undergoing definitive chemoradiation - Age>18 years - Signed informed consent
- Patients who meet exclusion criteria for MRI following the protocol of the department of Radiology of the UMC Utrecht. -Patients who meet exclusion criteria for Gadovist gadolinium (Glomerular Filtration Rate (GFR) of <35 mL/min/1.73m2, *according to clinical protocol*). - Patients with a known Gadovist allergy - Patients having difficulty understanding Dutch - History of previous radiotherapy for thoracic, gastric or head and neck tumors - Pregnant or breast-feeding patients
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method