Magnetic Resonance Imaging of the upper airway in childre
Recruiting
- Conditions
- aryngeal stenosis
- Registration Number
- NL-OMON26869
- Lead Sponsor
- Erasmus MC- Sophia Children's Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
Undergone surgical reconstruction for a congenital or acquired laryngeal stenosis between 1994 and 2011 (minimum 6 years of age), informed consent by parents and/or patient
Exclusion Criteria
Contra- indications for MRI, inability to undergo MRI, any current lung infection (symptoms of respiratory distress, severe cough, antibiotics for current lung infection), chronic oxygen need, tracheotomy cannula in situ
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary outcomes of this study are the findings on MRI. In the first sub study we will classify post-surgical changes. In the second sub study we will quantify the extent and location of fibrosis. Lastly, in the third sub study, we will quantify the mobility of the vocal cords.
- Secondary Outcome Measures
Name Time Method The MRI findings from the first and second sub study will be correlated to clinical status. Clinical status will be assessed through patient history, health related questionnaires, physical examination and spirometry. Findings from the third sub study will be correlated to the rate of dysphonia assessed by the Dysphonia Severity Index and voice questionnaires.