Magnetic resonance imaging of small airways in paediatric asthma
Not Applicable
- Conditions
- 10038716<p>Asthma</p>
- Registration Number
- NL-OMON20384
- Lead Sponsor
- Erasmus MC, University Medical Center Rotterdam
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 30
Inclusion Criteria
|
Astma patients: |
Exclusion Criteria
|
Een potentiële deelnemer die voldoet aan een van de volgende criteria zal worden uitgesloten van deelname aan dit onderzoek: |
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary study endpoint to investigate whether proton MRI can be used to provide us with new relevant information regarding the small airways and lung mechanics: - Ventilation defect (VD) on OE-MRI map and FD ventilation map expressed as % of total lung volume - Area of low intensity regions (LIR) on end-expiratory MR images expressed as a % of total lung volume</p><br>
- Secondary Outcome Measures
Name Time Method <p>- Lung volume - Normal lung tissue, expressed as % of total lung volume - Structural abnormalities: presence of airway wall thickening, mucus plugging, consolidations, atelectasis, etc. - Perfusion: areas of low intensity regions, expressed as % of the total lung volume and Fourier decomposition sequences showing a ventilation/perfusion map, with areas of perfusion defect, expressed as a % of total lung volume maps - Mechanical properties of the lung - Change in lung function tests pre- and post SABA - Difference in lung function tests between asthma patients and healthy volunteers - Correlation of mechanical, ventilation, perfusion and structural abnormalities on MRI with clinical parameters and lung function tests</p><br>