Magnetic resonance imaging of small airways in paediatric asthma
- Conditions
- asthma10006436
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 30
Asthma patients:
- Age 6-18 years
- Diagnosis of asthma for at least 6 months, in accordance with a paediatric
pulmonologist
- Small airways obstruction as assessed by pulmonary function testing, defined
as:
- Dissociation between FVC and FEF75 values: FEF75 at least 30%
(absolute % predicted) below FVC.
- FVC within normal limits (for this study defined as FVC >= 80%
predicted)
- Ability and will to perform spirometer controlled chest MRI
- Ability and will to provide written informed consent
Healthy Volunteers:
- Age 6-18 years
- Siblings or friend of the asthma patients
- No known pulmonary disease
- Ability and will to perform spirometer controlled chest MRI
- Ability and will to provide written informed consent
- MRI contraindication (cardiac pacemaker, metallic implant, hearing aids,etc.)
- Self-reported pregnancy
- Claustrophobia
- Use of SABA (e.g. albuterol or salbutamol) as escape medication <8 hours ago
- Use of LABA (e.g. formoterol or salmeterol) medication <48 hours ago
- Inability to follow instructions of the investigator
- Inability or not willing to perform spirometer controlled chest MRI
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Ventilation defect expressed as percentage of total lung volume on an oxygen<br /><br>enhanced MRI map and area of low intensity regions on end-expiratory magnetic<br /><br>resonance images.</p><br>
- Secondary Outcome Measures
Name Time Method