Magnetic resonance imaging of the upper airways in childre

Completed

Conditions: airway stenosis
laryngeal stenosis
10046304

Registration Number: NL-OMON46525

Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 50

Inclusion Criteria

Patient: undergone surgical reconstruction for a congenital or acquired laryngeal stenosis between 1994 and 2018( 6-30 years), able to follow instructions during MRI, informed consent by parents and/or patient
Volunteer: age between 6 and 30 years, able to follow instructions during MRI, informed consent by parents and/or volunteer

Exclusion Criteria

Patient: contra- indications for MRI, inability to undergo MRI, any current lung infection (symptoms of respiratory distress, severe cough, antibiotics for current lung infection), chronic oxygen need, tracheotomy cannula in situ
Volunteer: contra- indications for MRI, inability to undergo MRI, any current lung infection (symptoms of respiratory distress, severe cough, antibiotics for current lung infection), chronic oxygen need, co- morbidities of the lungs, airways or vocal cords

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcomes of this study are the findings on MRI. In the first sub<br /><br>study we will classify post-surgical changes, this will compared to the normal<br /><br>anatomy of the larynx in healthy children. In the second sub study we will<br /><br>quantify the extent and location of fibrosis. Lastly, in the third sub study,<br /><br>we will quantify the mobility of the vocal cords. This will compared to the<br /><br>normal vocal cord mobility as seen in healthy children. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The MRI findings from the first and second sub study will be correlated to<br /><br>clinical status. Clinical status will be assessed through health related<br /><br>questionnaires and spirometry. Findings from the third sub study will be<br /><br>correlated to the rate of dysphonia assessed by the Dysphonia Severity Index<br /><br>and voice questionnaires. </p><br>