Common and Differentiated Representations Between Social Exclusion and Social Separation

Not Applicable

Recruiting

• Conditions: Healthy
• Interventions: Drug: Intranasal placebo; Drug: Intranasal Arginine Vasopressin; Drug: Intranasal Oxytocin

• Registration Number: NCT05920707
• Lead Sponsor: University of Electronic Science and Technology of China

Brief Summary

Explore the shared or separated neural mechanisms of social exclusion and social segregation and compare differential effects of AVP and OXT on these social interaction function.

Detailed Description

A large body of research has shown that there are differences in the neural representation between social exclusion and social segregation, but the results are inconsistent, and the exploration of the neural basis is still insufficient. In addition, there are two mainstream theoretical explanations for these differences, namely the construction-level theory and the emotion-based theory, but there is no consistent theoretical model yet. Therefore, further exploration is necessary to confirm the cognitive and neural mechanisms underlying the differences between social exclusion and social segregation, and to attempt to reveal the theoretical explanations for these differences. In this project, the investigators propose to perform behavioral and functional magnetic resonance imaging (fMRI) techniques to examine the shared or separate neural mechanisms of social exclusion and social segregation (exp 1: social exclusion; exp 2: social separation) and investigate the modulatory effects of OXT/AVP on them (PLC/24IU OXT/20IU AVP).

Study Timeline

• Study Start: 2023-04-20
• Status Verified: 2023-06
• Study First Submitted: 2023-06-02
• Study First Submitted QC: 2023-06-16
• Study First Posted: 2023-06-27
• Last Update Submitted: 2023-06-27
• Last Update Posted: 2023-06-28
• Primary Completion: 2023-09-20
• Study Completion: 2023-10-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

1. Healthy subjects;
2. Without any past or present psychiatric or neurological disorders;
3. Without any current psychotherapeutic medication.

EXclusion Criteria:

1. With any past or present psychiatric or neurological disorders;
2. With any current psychotherapeutic medication.

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Intranasal placebo	Intranasal placebo	Administer placebo intranasally.
Intranasal Arginine Vasopressin	Intranasal Arginine Vasopressin	Administer Arginine Vasopressin (20 IU) intranasally.
Intranasal Oxytocin	Intranasal Oxytocin	Administer oxytocin (24 IU) intranasally.

Primary Outcome Measures

Name	Time	Method
Neural index: OXT and AVP effects on fMRI based- social exclusion and social separation tasks	45 minutes after treatment administration	Comparions between OXT and AVP on social exclusion and social separation on brain activity or representations
Behavioral index: behavioral ratings of social exclusion and social separation tasks	Immediately after fMRI scanning	Comparions between social exclusion and social separation in pain ratings

Trial Locations

Locations (1)

University of Electronic Science and Technology of China(UESTC); 🇨🇳 Chengdu, Sichuan, China