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临床试验/NCT05920707
NCT05920707招募中不适用

Common and Differentiated Representations Between Social Exclusion and Social Separation

University of Electronic Science and Technology of China1 个研究点 分布在 1 个国家目标入组 120 人开始时间: 2023年4月20日最近更新:
适应症
干预措施
相关药物

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
120
试验地点
1
主要终点
Neural index: OXT and AVP effects on fMRI based- social exclusion and social separation tasks

研究概览

简要总结

Explore the shared or separated neural mechanisms of social exclusion and social segregation and compare differential effects of AVP and OXT on these social interaction function.

详细描述

A large body of research has shown that there are differences in the neural representation between social exclusion and social segregation, but the results are inconsistent, and the exploration of the neural basis is still insufficient. In addition, there are two mainstream theoretical explanations for these differences, namely the construction-level theory and the emotion-based theory, but there is no consistent theoretical model yet. Therefore, further exploration is necessary to confirm the cognitive and neural mechanisms underlying the differences between social exclusion and social segregation, and to attempt to reveal the theoretical explanations for these differences. In this project, the investigators propose to perform behavioral and functional magnetic resonance imaging (fMRI) techniques to examine the shared or separate neural mechanisms of social exclusion and social segregation (exp 1: social exclusion; exp 2: social separation) and investigate the modulatory effects of OXT/AVP on them (PLC/24IU OXT/20IU AVP).

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Basic Science
盲法
Triple (Participant, Investigator, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 30 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Healthy subjects;
  • Without any past or present psychiatric or neurological disorders;
  • Without any current psychotherapeutic medication.
  • EXclusion Criteria:
  • With any past or present psychiatric or neurological disorders;
  • With any current psychotherapeutic medication.

排除标准

  • 未提供

研究组 & 干预措施

Intranasal Oxytocin

Active Comparator

Administer oxytocin (24 IU) intranasally.

干预措施: Intranasal Oxytocin (Drug)

Intranasal Arginine Vasopressin

Active Comparator

Administer Arginine Vasopressin (20 IU) intranasally.

干预措施: Intranasal Arginine Vasopressin (Drug)

Intranasal placebo

Placebo Comparator

Administer placebo intranasally.

干预措施: Intranasal placebo (Drug)

结局指标

主要结局

Neural index: OXT and AVP effects on fMRI based- social exclusion and social separation tasks

时间窗: 45 minutes after treatment administration

Comparions between OXT and AVP on social exclusion and social separation on brain activity or representations

Behavioral index: behavioral ratings of social exclusion and social separation tasks

时间窗: Immediately after fMRI scanning

Comparions between social exclusion and social separation in pain ratings

次要结局

未报告次要终点

研究者

发起方
University of Electronic Science and Technology of China
申办方类型
Other
责任方
Principal Investigator
主要研究者

Weihua Zhao

Associate Professor

University of Electronic Science and Technology of China

研究点 (1)

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