Common and Differentiated Representations Between Social Exclusion and Social Separation
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Neural index: OXT and AVP effects on fMRI based- social exclusion and social separation tasks
研究概览
简要总结
Explore the shared or separated neural mechanisms of social exclusion and social segregation and compare differential effects of AVP and OXT on these social interaction function.
详细描述
A large body of research has shown that there are differences in the neural representation between social exclusion and social segregation, but the results are inconsistent, and the exploration of the neural basis is still insufficient. In addition, there are two mainstream theoretical explanations for these differences, namely the construction-level theory and the emotion-based theory, but there is no consistent theoretical model yet. Therefore, further exploration is necessary to confirm the cognitive and neural mechanisms underlying the differences between social exclusion and social segregation, and to attempt to reveal the theoretical explanations for these differences. In this project, the investigators propose to perform behavioral and functional magnetic resonance imaging (fMRI) techniques to examine the shared or separate neural mechanisms of social exclusion and social segregation (exp 1: social exclusion; exp 2: social separation) and investigate the modulatory effects of OXT/AVP on them (PLC/24IU OXT/20IU AVP).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 30 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy subjects;
- •Without any past or present psychiatric or neurological disorders;
- •Without any current psychotherapeutic medication.
- •EXclusion Criteria:
- •With any past or present psychiatric or neurological disorders;
- •With any current psychotherapeutic medication.
排除标准
- 未提供
研究组 & 干预措施
Intranasal Oxytocin
Administer oxytocin (24 IU) intranasally.
干预措施: Intranasal Oxytocin (Drug)
Intranasal Arginine Vasopressin
Administer Arginine Vasopressin (20 IU) intranasally.
干预措施: Intranasal Arginine Vasopressin (Drug)
Intranasal placebo
Administer placebo intranasally.
干预措施: Intranasal placebo (Drug)
结局指标
主要结局
Neural index: OXT and AVP effects on fMRI based- social exclusion and social separation tasks
时间窗: 45 minutes after treatment administration
Comparions between OXT and AVP on social exclusion and social separation on brain activity or representations
Behavioral index: behavioral ratings of social exclusion and social separation tasks
时间窗: Immediately after fMRI scanning
Comparions between social exclusion and social separation in pain ratings
次要结局
未报告次要终点
研究者
Weihua Zhao
Associate Professor
University of Electronic Science and Technology of China
