Neural Mechanism Underlying Social Cognition in Depressive Patients

• Conditions: Depression

• Registration Number: NCT03413670
• Lead Sponsor: Beijing Normal University

Brief Summary

In the project, investigators plan to test difference of social cognition between depressive patients and healthy individuals and the brain activation underlying the difference to further understand the neural mechanism of depressive disorder.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-01-01
• Study First Submitted: 2018-01-22
• Study First Submitted QC: 2018-01-22
• Study First Posted: 2018-01-29
• Status Verified: 2018-02
• Last Update Submitted: 2018-02-05
• Last Update Posted: 2018-02-07
• Primary Completion: 2018-02-08
• Study Completion: 2018-03-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• Age range between 18 and 60
• Education experience above high school
• Score for Hamilton's Depression Scale >=17
• Diagnosis of depression through Scid

Exclusion Criteria

• Undergoing electric shock treatment in 3 months
• Excluding those who with bipolar disorder
• Excluding those who with postpartum depression
• Excluding those who with hysteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
emotion recognition	Baseline	After viewing a video, participants will be asked to judge the person's attitude in the video. Through this paradigm, investigators could test emotional bias in social interaction in depressive patients.
resting state	Baseline	In this part, investigators basically want to test the automatic neural activity for depressive patients while they are resting.
self-reflection	Baseline	Participants will be asked to judge the discrepancy between actual self and ideal self.
white matter	Baseline	Investigators scanned DTI to detect the difference between clinical population and healthy population.
structure	Baseline	Investigators scanned structural images to detect the difference between clinical population and healthy population.
response to negative stimuli	Baseline	investigators used face-matching task to measure their response to negative stimuli. The participants will be asked to detect the identical face with same emotion.

Trial Locations

Locations (1)

Huilongguan Hospital; 🇨🇳 Beijing, China