Neural Mechanism Underlying Social Cognition in Depressive Patients
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- emotion recognition
研究概览
简要总结
In the project, investigators plan to test difference of social cognition between depressive patients and healthy individuals and the brain activation underlying the difference to further understand the neural mechanism of depressive disorder.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age range between 18 and 60
- •Education experience above high school
- •Score for Hamilton's Depression Scale >=17
- •Diagnosis of depression through Scid
排除标准
- •Undergoing electric shock treatment in 3 months
- •Excluding those who with bipolar disorder
- •Excluding those who with postpartum depression
- •Excluding those who with hysteria
结局指标
主要结局
emotion recognition
时间窗: Baseline
After viewing a video, participants will be asked to judge the person's attitude in the video. Through this paradigm, investigators could test emotional bias in social interaction in depressive patients.
resting state
时间窗: Baseline
In this part, investigators basically want to test the automatic neural activity for depressive patients while they are resting.
self-reflection
时间窗: Baseline
Participants will be asked to judge the discrepancy between actual self and ideal self.
white matter
时间窗: Baseline
Investigators scanned DTI to detect the difference between clinical population and healthy population.
response to negative stimuli
时间窗: Baseline
investigators used face-matching task to measure their response to negative stimuli. The participants will be asked to detect the identical face with same emotion.
structure
时间窗: Baseline
Investigators scanned structural images to detect the difference between clinical population and healthy population.
次要结局
未报告次要终点
研究者
ma, yina
Principal Investigator
Beijing Normal University