Effect of Inspiratory Muscle Training on Ventilated Patients in an Intensive Care Unit
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Number of days until liberation from mechanical ventilation
研究概览
简要总结
The goal of this clinical trial is to learn if inspiratory muscle training facilite the liberation of mechanical ventilation. The main questions it aims to answer are:
Does inspiratory muscle training facilitate weaning from mechanical ventilation and enhance muscle strength in critically ill, subacute adult patients?
The main questions it aims to answer are:
Does pulmonary rehabilitation facilitate wwaning form mechanical patients? Does the intervention improve respiratory muscle strength and respiratory patterns?
Participants received:
Inspriatory muscle training twice daily for three consecutive weeks or until the subject no longer required ventilator support.
详细描述
Patients on mechanical ventilation often experience rapid diaphragm atrophy on the second day, resulting in muscle fiber changes, respiratory muscle weakness. Clinical studies have explored enhancing diaphragm and respiratory muscle strength and endurance through inspiratory muscle, expiratory muscle, and combined respiratory muscle training. This study was to determine if inspiratory muscle training significantly facilitates liberation from mechanical ventilation and improves muscle strength when compared to without IMT among subacute critically ill adult patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •requiring invasive mechanical ventilation for 2 days in an ICU
排除标准
- •hemodynamic instability (heart rate 120 beats/min, unstable blood pressure, vasopressor infusion)
- •inadequate oxygenation (PEEP 8 cmH2O, FiO2 50%)
- •body temperature 38.5°C
- •use of sedative infusion
- •steroid administration
- •home ventilator use before ICU admission
结局指标
主要结局
Number of days until liberation from mechanical ventilation
时间窗: Three weeks
A record of the number of days until liberation from mechanical ventilation.
次要结局
- Peak inspiratory flow(Three weeks)
- Maximum inspiratory pressure(Three weeks)
- Maximum expiratory pressure(Three weeks)
- Peak expiratory flow(Three weeks)
- Rapid Shallow breathing index(Three weeks)
研究者
Hui-Ling Lin
Professor
Chang Gung University