Effect of Dexamethasone and Epinephrine on the Duration of Sciatic Nerve Blocks With Ropivacaine

Not Applicable

• Conditions: Postoperative Pain
• Interventions: Drug: Dexamethasone; Drug: Epinephrine

• Registration Number: NCT02104778
• Lead Sponsor: Yeungnam University College of Medicine

Brief Summary

The aim of the present study is to test that adding dexamethasone or epinephrine significantly prolongs the duration of sciatic nerve blocks with ropivacaine and that the magnitude of the effect differs among dexamethasone and epinehrine.

Detailed Description

In a double-blinded trial utilizing single-injection sciatic nerve block, patients are randomly assigned to one of three groups: control: 0.5% ropivacaine adding normal saline; epinephrine: 0.5% ropivacaine adding epinephrine; dexamethasone: 0.5% ropivacaine adding dexamethasone. We assess time to first analgesic request after post-anaesthesia care unit discharge.

Study Timeline

• Study Start: 2014-04
• Study First Submitted: 2014-04-01
• Study First Submitted QC: 2014-04-03
• Study First Posted: 2014-04-04
• Status Verified: 2015-07
• Last Update Submitted: 2015-07-14
• Last Update Posted: 2015-07-16
• Primary Completion: 2016-06
• Study Completion: 2016-07

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• American Society of Anesthesiologists physical status I and II
• patients undergoing elective hallux valgus repair

Exclusion Criteria

• patients receiving chronic analgesic therapy
• diabetes
• peripheral neuropathies
• psychiatric disorders
• hypersensitivity to amide local anesthetics
• renal disorders

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Dexamethasone	Dexamethasone	Dexamethasone 8 mg is added to 0.5% ropivacaine 20 ml for sciatic nerve block.
epinephrine	Epinephrine	Epinephrine 1:200,000 is added to 0.5% ropivacaine 20 ml for sciatic nerve block.

Primary Outcome Measures

Name	Time	Method
time to first analgesic request after postanesthetic care unit discharge	from arrival in postanesthetic care unit to 72 hours after operation	A blinded observer interview patients at arrival in postanesthetic care unit, 6 hour, 24 hour, 48 hour, 72 hour after operation.

Secondary Outcome Measures

Name	Time	Method
time of recovery of motor and sensory functions on the operated foot	from arrival in postanesthetic care unit to 72 hours after operation	The time of recovery of motor (ability to move the ankle) and sensory (recovery of normal pinprick sensation) functions on the operated foot is recorded by the blinded observer at arrival in postanesthetic care unit, 6 hour, 24 hour, 48 hour, 72 hour after operation.

Trial Locations

Locations (1)

Department of Anesthesiology and Pain Medicine, Yeungnam University hospital; 🇰🇷 Daegu, Korea, Republic of