Dexamethasone as an Adjuvant in Supraclavicular Block

Phase 2

• Conditions: Dexamethasone Efficacy as an Adjuvant in Supraclavicular Block
• Interventions: Drug: Dexamethasone injection

• Registration Number: NCT04345588
• Lead Sponsor: Assiut University

Brief Summary

The use of dexamethasone perineurally along with local anesthetic has been shown to improve the duration of analgesia .

Detailed Description

Acute postoperative pain can be effectively controlled with the use of peripheral nerve blocks. Use of additives further prolongs the duration of analgesia For upper limb surgeries below shoulder joint, the brachial plexus block using supraclavicular approach introduced by Kulenkampff has gained popularity. Supraclavicular approach to brachial plexus block is useful for procedures done at or below the level of elbow.

This technique involves the deposition of local anesthetic near the brachial plexus approached from immediately above the clavicle. Brachial plexus is formed by ventral rami of C5, C6, C7, C8, and T1 which forms the roots.These then continue distally to form trunks, divisions, cords,and branches Local anesthetics used alone in supraclavicular block provide analgesia for 4-8 h.

The use of dexamethasone perineurally along with local anesthetic has been shown to improve the duration of analgesia. Intravenous dexamethasone is also useful in attenuating the postoperative need for analgesics in different clinical settings even in the absence of any nerve blocks.

Hence, it is logical to compare the duration of analgesia with the use of dexamethasone in the setting of supraclavicular brachial plexus block, dexamethasone given either perineurally or intravenously.

Study Timeline

• Status Verified: 2020-04
• Study First Submitted: 2020-04-10
• Study First Submitted QC: 2020-04-13
• Last Update Submitted: 2020-04-13
• Study First Posted: 2020-04-14
• Last Update Posted: 2020-04-14
• Study Start: 2021-01-01
• Primary Completion: 2022-01-01
• Study Completion: 2022-06-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• 1. Patients between 18 and 60 years of age 2. Both male and female gender 3. ASA physical status Classes I and II patients 4. Patients posted for upper limb surgery below shoulder.

Exclusion Criteria

• 1. Patient refusal 2. Patients with bleeding disorders and those on anticoagulant therapy 3. History of allergy to local anesthetics 4. Infection at the site of block 5. Neuro deficit involving brachial plexus 6. Pregnant women 7. Patients with psychiatric behavior 8. ASA physical status Classes III and IV patients

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
group received dexamethasone perineural	Dexamethasone injection	injection dexamethasone 0.05 mg/kg perineural.
group received dexamethasone intravenous	Dexamethasone injection	injection dexamethasone 0.05 mg/kg intravenously.

Primary Outcome Measures

Name	Time	Method
Dexamethasone efficacy as an Adjuvant in Supraclavicular Block	2 years	we will assess the efficacy of dexamethasone in supraclavicular anaethesia in terms of duration of analgesia and onset of motor and sensory block.