Comparison Between Perineural and Systemic Effect of Dexamethasone as an Adjuvant for Prolongation of Four Nerve Blocks With Bupivacaine in Total Knee Arthroplasty
Not Applicable
Completed
- Conditions
- Pain, PostoperativeAnalgesia
- Interventions
- Registration Number
- NCT02253784
- Lead Sponsor
- Hillel Yaffe Medical Center
- Brief Summary
The addition of dexamethasone (DxaM) to local anesthetic may significantly prolong the duration of a block in total knee arthroplasty. The aim of this study is to determine whether this is a systemic or local effect.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 90
Inclusion Criteria
- Pre-surgical total knee arthroplasty patients
Exclusion Criteria
- Skin infection near block site
- Allergy to local anesthetics
- Peripheral neuropathy
- Proven opioid dependency
- Coagulopathy
- Dementia
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Group I (ISB-P) Bupivacaine Four nerve blocks with perineural injection of dexamethasone 0.1 mg/kg and bupivacaine 0.5% - 45 ml Group I (ISB-P) Dexamethasone Four nerve blocks with perineural injection of dexamethasone 0.1 mg/kg and bupivacaine 0.5% - 45 ml Group II (ISB-S) Dexamethasone Four nerve blocks with systemic injection of dexamethasone 0.1 mg/kg and bupivacaine 0.5% - 45 ml Group II (ISB-S) Bupivacaine Four nerve blocks with systemic injection of dexamethasone 0.1 mg/kg and bupivacaine 0.5% - 45 ml Group III (ISB-C) Bupivacaine Four nerve blocks without dexamethasone
- Primary Outcome Measures
Name Time Method Efficacy Perineural DxaM One day Duration of motor and sensory block
- Secondary Outcome Measures
Name Time Method Efficacy of Systemic DxaM One day Duration of motor and sensory block
Trial Locations
- Locations (1)
Hillel Yaffe Medical Center
🇮🇱Hadera, Israel