Effect of Heated-humidified Circuit on Arterial Oxygenation in Patients Undergoing One-lung Ventilation for Thoracoscopic Surgery
Trial Snapshot
- Phase
- Not Applicable
- Enrollment
- 104
- Primary Endpoint
- Arterial oxygenation
Study Overview
Brief Summary
One-lung ventilation interrupts oxygenation. The effect of heated humidifed breathing circuit on arterial oxygenation during one-lung ventilation has not been investigated. The investigators will investigate the effect of the heated humidifed breathing circuit on oxygenation during one-lung ventilation in patients undergoing thoracoscopic surgery.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Supportive Care
- Masking
- Triple (Participant, Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 19 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •American Society of Anesthesiologist class I-II
- •Patients scheduled for one-lung ventilation for thoracoscopic surgery
Exclusion Criteria
- •Severe obstructive or restrictive lung disease
- •Preoperative oxygen supply
- •Preoperative intubated state or under mechanical ventilatory support
- •Baseline arterial partial pressure of oxygen (PaO2) < 70 mmHg
- •Symptomatic coronary or peripheral arterial disease
- •Renal failure
- •Preoperative continuous infusion of inotropes or vasopressor
- •Pregnancy
Arms & Interventions
Control
Heated breathing circuit will turned off.
Intervention: Heated and humidified breathing circuit off (Device)
Heat
Heated breathing circuit will be turned on.
Intervention: Heated and humidified breathing circuit on (Device)
Outcomes
Primary Outcomes
Arterial oxygenation
Time Frame: At 30 minutes after one-lung ventilation
Arterial oxygenation (mmHg) will be measured by arterial blood analysis.
Secondary Outcomes
- Heart rate(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)
- Temperature(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)
- Central venous pressure(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)
- Cardiac index(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)
- Pressure peak(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)
- Pressure plateau(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)
- Arterial oxygenation(At 0, 15, 45, and 60 minutes after one-lung ventilation)
- Arterial carbon dioxide(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)
- Oxygen saturation of arterial blood(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)
- Mean arterial pressure(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)
- Arterial blood acidosis(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)
Investigators
Hyun-Chang Kim
Assistant professor
Keimyung University Dongsan Medical Center