Heated Circuit for One-lung Ventilation

Not Applicable

• Conditions: Oxygenation; Temperature; One-lung Ventilation
• Interventions: Device: Heated and humidified breathing circuit off; Device: Heated and humidified breathing circuit on

• Registration Number: NCT03649386
• Lead Sponsor: Keimyung University Dongsan Medical Center

Brief Summary

One-lung ventilation interrupts oxygenation. The effect of heated humidifed breathing circuit on arterial oxygenation during one-lung ventilation has not been investigated. The investigators will investigate the effect of the heated humidifed breathing circuit on oxygenation during one-lung ventilation in patients undergoing thoracoscopic surgery.

Detailed Description

Not available

Study Timeline

• Status Verified: 2018-08
• Study First Submitted: 2018-08-22
• Study First Submitted QC: 2018-08-27
• Last Update Submitted: 2018-08-27
• Study First Posted: 2018-08-28
• Last Update Posted: 2018-08-28
• Study Start: 2018-09-01
• Primary Completion: 2019-09-01
• Study Completion: 2019-12-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 104

Inclusion Criteria

• American Society of Anesthesiologist class I-II
• Patients scheduled for one-lung ventilation for thoracoscopic surgery

Exclusion Criteria

• Obesity
• Severe obstructive or restrictive lung disease
• Preoperative oxygen supply
• Preoperative intubated state or under mechanical ventilatory support
• Baseline arterial partial pressure of oxygen (PaO2) < 70 mmHg
• Symptomatic coronary or peripheral arterial disease
• Renal failure
• Preoperative continuous infusion of inotropes or vasopressor
• Pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control	Heated and humidified breathing circuit off	Heated breathing circuit will turned off.
Heat	Heated and humidified breathing circuit on	Heated breathing circuit will be turned on.

Primary Outcome Measures

Name	Time	Method
Arterial oxygenation	At 30 minutes after one-lung ventilation	Arterial oxygenation (mmHg) will be measured by arterial blood analysis.

Secondary Outcome Measures

Name	Time	Method
Heart rate	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation	Heart rate (beats/min) will be measured.
Temperature	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation	Body temperature (°C) will be measured.
Central venous pressure	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation	Mean central venous pressure (mmHg) will be measured by a central venous catheter.
Cardiac index	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation	Cardiac index (l/min/m\^2) will be measured by pulse-contour analysis.
Pressure peak	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation	Peak pressure of ventilation (cmH2O) will be measured.
Pressure plateau	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation	Plateau pressure of ventilation (cmH2O) will be measured.
Arterial oxygenation	At 0, 15, 45, and 60 minutes after one-lung ventilation	Arterial oxygenation (mmHg) will be measured by arterial blood analysis.
Arterial carbon dioxide	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation	Arterial carbon dioxide will be measured.
Oxygen saturation of arterial blood	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation	Oxygen saturation of arterial blood (%) will be measured.
Mean arterial pressure	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation	Mean arterial pressure (mmHg) will be measured.
Arterial blood acidosis	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation	Arterial blood acidosis will be measured.