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Clinical Trials/NCT03649386
NCT03649386UnknownNot Applicable

Effect of Heated-humidified Circuit on Arterial Oxygenation in Patients Undergoing One-lung Ventilation for Thoracoscopic Surgery

Keimyung University Dongsan Medical Center0 sites104 target enrollmentStarted: September 1, 2018Last updated:
Conditions
Interventions

Trial Snapshot

Phase
Not Applicable
Enrollment
104
Primary Endpoint
Arterial oxygenation

Study Overview

Brief Summary

One-lung ventilation interrupts oxygenation. The effect of heated humidifed breathing circuit on arterial oxygenation during one-lung ventilation has not been investigated. The investigators will investigate the effect of the heated humidifed breathing circuit on oxygenation during one-lung ventilation in patients undergoing thoracoscopic surgery.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Supportive Care
Masking
Triple (Participant, Investigator, Outcomes Assessor)

Eligibility Criteria

Ages
19 Years to 80 Years (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • American Society of Anesthesiologist class I-II
  • Patients scheduled for one-lung ventilation for thoracoscopic surgery

Exclusion Criteria

  • Severe obstructive or restrictive lung disease
  • Preoperative oxygen supply
  • Preoperative intubated state or under mechanical ventilatory support
  • Baseline arterial partial pressure of oxygen (PaO2) < 70 mmHg
  • Symptomatic coronary or peripheral arterial disease
  • Renal failure
  • Preoperative continuous infusion of inotropes or vasopressor
  • Pregnancy

Arms & Interventions

Control

Active Comparator

Heated breathing circuit will turned off.

Intervention: Heated and humidified breathing circuit off (Device)

Heat

Experimental

Heated breathing circuit will be turned on.

Intervention: Heated and humidified breathing circuit on (Device)

Outcomes

Primary Outcomes

Arterial oxygenation

Time Frame: At 30 minutes after one-lung ventilation

Arterial oxygenation (mmHg) will be measured by arterial blood analysis.

Secondary Outcomes

  • Heart rate(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)
  • Temperature(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)
  • Central venous pressure(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)
  • Cardiac index(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)
  • Pressure peak(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)
  • Pressure plateau(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)
  • Arterial oxygenation(At 0, 15, 45, and 60 minutes after one-lung ventilation)
  • Arterial carbon dioxide(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)
  • Oxygen saturation of arterial blood(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)
  • Mean arterial pressure(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)
  • Arterial blood acidosis(At 0, 15, 30, 45, and 60 minutes after one-lung ventilation)

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Hyun-Chang Kim

Assistant professor

Keimyung University Dongsan Medical Center

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