Heated Circuit for One-lung Ventilation

Not Applicable

• Conditions: Oxygenation; Temperature; One-lung Ventilation

• Registration Number: NCT03649386
• Lead Sponsor: Keimyung University Dongsan Medical Center

Brief Summary

One-lung ventilation interrupts oxygenation. The effect of heated humidifed breathing circuit on arterial oxygenation during one-lung ventilation has not been investigated. The investigators will investigate the effect of the heated humidifed breathing circuit on oxygenation during one-lung ventilation in patients undergoing thoracoscopic surgery.

Detailed Description

Not available

Study Timeline

• Status Verified: 2018-08
• Study First Submitted: 2018-08-22
• Study First Submitted QC: 2018-08-27
• Last Update Submitted: 2018-08-27
• Study First Posted: 2018-08-28
• Last Update Posted: 2018-08-28
• Study Start: 2018-09-01
• Primary Completion: 2019-09-01
• Study Completion: 2019-12-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 104

Inclusion Criteria

• American Society of Anesthesiologist class I-II
• Patients scheduled for one-lung ventilation for thoracoscopic surgery

Exclusion Criteria

• Obesity
• Severe obstructive or restrictive lung disease
• Preoperative oxygen supply
• Preoperative intubated state or under mechanical ventilatory support
• Baseline arterial partial pressure of oxygen (PaO2) < 70 mmHg
• Symptomatic coronary or peripheral arterial disease
• Renal failure
• Preoperative continuous infusion of inotropes or vasopressor
• Pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Arterial oxygenation	At 30 minutes after one-lung ventilation	Arterial oxygenation (mmHg) will be measured by arterial blood analysis.

Secondary Outcome Measures

Name	Time	Method
Heart rate	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation	Heart rate (beats/min) will be measured.
Temperature	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation	Body temperature (°C) will be measured.
Central venous pressure	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation	Mean central venous pressure (mmHg) will be measured by a central venous catheter.
Cardiac index	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation	Cardiac index (l/min/m\^2) will be measured by pulse-contour analysis.
Pressure peak	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation	Peak pressure of ventilation (cmH2O) will be measured.
Pressure plateau	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation	Plateau pressure of ventilation (cmH2O) will be measured.
Arterial oxygenation	At 0, 15, 45, and 60 minutes after one-lung ventilation	Arterial oxygenation (mmHg) will be measured by arterial blood analysis.
Arterial carbon dioxide	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation	Arterial carbon dioxide will be measured.
Oxygen saturation of arterial blood	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation	Oxygen saturation of arterial blood (%) will be measured.
Mean arterial pressure	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation	Mean arterial pressure (mmHg) will be measured.
Arterial blood acidosis	At 0, 15, 30, 45, and 60 minutes after one-lung ventilation	Arterial blood acidosis will be measured.