Effect of Motor Function, Depression and Sleep Quality on Attention in Parkinson's Disease
Trial Snapshot
- Phase
- Not Applicable
- Status
- Enrolling By Invitation
- Sponsor
- Inonu University
- Enrollment
- 54
- Locations
- 1
- Primary Endpoint
- 30 sec sit-stand test
Study Overview
Brief Summary
Our study was planned to analyze motor function, endurance and sleep attention information in Parkinson's patients with detailed and objective measurements.
Detailed Description
Parkinson's Disease (PD) is a neurodegenerative disease that occurs with the loss of dopaminergic neurons in the basal ganglia (BG) and subsequently affects multiple brain regions. There are studies that evaluate executive functions rather than cognitive functions in Parkinson's patients. However, objective evaluations of the attention parameter are quite rare. Accordingly, our study was planned to examine the effects of motor function, depression and sleep on attention in Parkinson's patients with detailed and objective measurements. Parkinson's patients (n=27) and healthy controls (n=27) aged between 40-85 will be included in the study. Balance evaluation of the individuals participating in the study was carried out by functional reaching test, one-leg standing test and Berg balance scale; Endurance with a 30-second sit-and-stand test; reaction time; with mobile application; muscle strength by hand dynamometer; functional mobility with time up and go test; walking speed, with 10 m walk test; attention with the P300 device; depression, with the Beck depression scale; Sleep quality will be assessed with the Pittsburg sleep questionnaire. At the end of the study, the effects of motor functions, sleep and depression on attention will be examined and compared with healthy controls.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 40 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Being 1,2 or 3 according to the Hoehn and yahr scale
- •Being between the ages of 40-85
- •Being diagnosed with Parkinson's according to UPDS
- •Being able to read and write
- •Being able to walk independently
- •Agreeing to participate in the study after providing detailed information about the research.
- •Mini mental test>24
Exclusion Criteria
- •Having severe hearing/visual impairment-loss
- •Having an orthopedic, neurological or metabolic disease that may interfere with working
- •Having deep brain stimulation applied
- •Those with advanced cognitive impairment
- •Individuals with dementia
- •Patients taking anticholinergic, antidepressive or anxiolytic medications that may affect cognition, and those with other medical or neurological causes that may cause cognitive effects.
Outcomes
Primary Outcomes
30 sec sit-stand test
Time Frame: again,day 1, higher results indicate better values, lower results indicate worse results
endurance
berg balance test
Time Frame: score, day 1, The score is between 0-56. A high total score indicates a good result
balance
hand dinamometer
Time Frame: kilogram, day 1, higher results indicate better values, lower results indicate worse results
strenght
functional reach test
Time Frame: centimeter, day 1, higher results indicate better values, lower results indicate worse results
balance
TUG
Time Frame: second, day 1, Values over 12 seconds indicate the risk of falling
functional mobility
10 m walking test
Time Frame: second, day 1, lower results indicate better values, higher results indicate worse results
walking speed
one leg stance test
Time Frame: second, day 1, higher results indicate better values, lower results indicate worse results
balance
mobil application
Time Frame: second, day 1, lower results indicate better values, higher results indicate worse results
reaction time
Pittsburg Sleep Quality İndex
Time Frame: score, day 1, The score is between 0-21. A high total score indicates a bad result.
sleep
Beck Depression
Time Frame: score,day 1, The total score is between 0-63. A high total score indicates that the result is bad.
depression
P300
Time Frame: second, day 1, lower results indicate better values, higher results indicate worse results
attention
Secondary Outcomes
No secondary outcomes reported
Investigators
Burcu Talu
Assoc.Prof.
Inonu University