Effect of Motor Function, Depression and Sleep Quality on Attention in Parkinson's Disease

• Conditions: Attention Impaired; Movement Disorders (Incl Parkinsonism); Parkinsonian Disorders; Movement Disorders, Functional

• Registration Number: NCT06283043
• Lead Sponsor: Inonu University

Brief Summary

Our study was planned to analyze motor function, endurance and sleep attention information in Parkinson's patients with detailed and objective measurements.

Detailed Description

Parkinson's Disease (PD) is a neurodegenerative disease that occurs with the loss of dopaminergic neurons in the basal ganglia (BG) and subsequently affects multiple brain regions. There are studies that evaluate executive functions rather than cognitive functions in Parkinson's patients. However, objective evaluations of the attention parameter are quite rare. Accordingly, our study was planned to examine the effects of motor function, depression and sleep on attention in Parkinson's patients with detailed and objective measurements. Parkinson's patients (n=27) and healthy controls (n=27) aged between 40-85 will be included in the study. Balance evaluation of the individuals participating in the study was carried out by functional reaching test, one-leg standing test and Berg balance scale; Endurance with a 30-second sit-and-stand test; reaction time; with mobile application; muscle strength by hand dynamometer; functional mobility with time up and go test; walking speed, with 10 m walk test; attention with the P300 device; depression, with the Beck depression scale; Sleep quality will be assessed with the Pittsburg sleep questionnaire. At the end of the study, the effects of motor functions, sleep and depression on attention will be examined and compared with healthy controls.

Study Timeline

• Study Start: 2024-01-01
• Status Verified: 2024-02
• Study First Submitted: 2024-02-13
• Study First Submitted QC: 2024-02-21
• Last Update Submitted: 2024-02-21
• Study First Posted: 2024-02-28
• Last Update Posted: 2024-02-28
• Primary Completion: 2024-03-01
• Study Completion: 2024-03-05

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 54

Inclusion Criteria

• Being 1,2 or 3 according to the Hoehn and yahr scale
• Being between the ages of 40-85
• Being diagnosed with Parkinson's according to UPDS
• Being able to read and write
• Being able to walk independently
• Agreeing to participate in the study after providing detailed information about the research.
• Mini mental test>24

Exclusion Criteria

• Having severe hearing/visual impairment-loss
• Having an orthopedic, neurological or metabolic disease that may interfere with working
• Having deep brain stimulation applied
• Those with advanced cognitive impairment
• Individuals with dementia
• Patients taking anticholinergic, antidepressive or anxiolytic medications that may affect cognition, and those with other medical or neurological causes that may cause cognitive effects.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
30 sec sit-stand test	again,day 1, higher results indicate better values, lower results indicate worse results	endurance
berg balance test	score, day 1, The score is between 0-56. A high total score indicates a good result	balance
hand dinamometer	kilogram, day 1, higher results indicate better values, lower results indicate worse results	strenght
functional reach test	centimeter, day 1, higher results indicate better values, lower results indicate worse results	balance
TUG	second, day 1, Values over 12 seconds indicate the risk of falling	functional mobility
10 m walking test	second, day 1, lower results indicate better values, higher results indicate worse results	walking speed
one leg stance test	second, day 1, higher results indicate better values, lower results indicate worse results	balance
mobil application	second, day 1, lower results indicate better values, higher results indicate worse results	reaction time
Pittsburg Sleep Quality İndex	score, day 1, The score is between 0-21. A high total score indicates a bad result.	sleep
Beck Depression	score,day 1, The total score is between 0-63. A high total score indicates that the result is bad.	depression
P300	second, day 1, lower results indicate better values, higher results indicate worse results	attention

Trial Locations

Locations (1)

Inonu University; 🇹🇷 Malatya, Battalgazi, Turkey