Effects of Zinc Supplementation on Anthropometric Factors, Apelin and Inflammatory Markers in Obese Individuals
Phase 2
Completed
- Conditions
- Obesity
- Interventions
- Dietary Supplement: zinc sulfateOther: corn starch
- Registration Number
- NCT02516475
- Lead Sponsor
- National Nutrition and Food Technology Institute
- Brief Summary
To study the effects of zinc supplement on anthropometric factors, Apelin and inflammatory markers in obese individuals, 50 obes person who referred to Diet and Nutrition clinic of Shahid Beheshti University of Medical Sciences will be randomly allocated to receive 50 mg zinc capsules or placebos for 15 weeks; both groups will be advised to adherence the investigators' diet . At the first and the end of the intervention,weight, body mass index (BMI), waist circumference, fat mass and lean body mass, concentration of zinc, albumin, hs-CRP, TNF-α and plasma apelin will be assessed and compared between groups.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
- Age of 18 to 45 years
- Non-smoking
- Body Mass Index (BMI) more than 30
Exclusion Criteria
- Pregnancy, lactation or menopause in women
- History of liver disease, kidney, thyroid, diabetes and other metabolic diseases
- Use of drugs interfering with lipid profile, blood-thinning drugs, beta-blockers
- Patients with immune deficiency
- Use of zinc, calcium and iron supplement in the last 2 months
- Use of weight loss medication or special diet
- Following program to lose weight in recent 2 months
- Recent surgery
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description zinc sulfate zinc sulfate 1 zinc sulfate capsule for 15 weeks starch corn starch 1 corn starch capsule for 15 weeks
- Primary Outcome Measures
Name Time Method weight 15 weeks
- Secondary Outcome Measures
Name Time Method