Study on pulmonary parenchymal destruction in bronchial asthma
Not Applicable
Recruiting
- Conditions
- Study on pulmonary parenchymal destruction in asthma
- Registration Number
- JPRN-UMIN000050641
- Lead Sponsor
- Ministry of Health, Labour and Welfare
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 25
Inclusion Criteria
Not provided
Exclusion Criteria
1 Those who have a complication of respiratory disease other than the present illness of surgery, asthma, or COPD. 2 Those deemed inappropriate as subjects by the principal investigator
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method CT pulmonary parenchymal destruction index (Exponent D, low attenuation area percent), pathological index (alveolar space length (mean linear intercept), number of alveolar attachments, number of terminal bronchioles) in resected lung specimens
- Secondary Outcome Measures
Name Time Method Exploratory evaluation using mRNA microarray, Pulmonary elastic fiber-related factors including collagen I, collagen III, fibronectin, matrix metalloproteinase (MMP)-1,MMP-2, MMP-9, tissue inhibitor of metalloproteinase (TIMP)