NCT05835401CompletedNot Applicable
Effects of Dietary Nitrate Intake on Cardiovascular Performance in Response to Hand Grip Test in Bodybuilders
Conditions
Interventions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Sao Paulo
- Enrollment
- 13
- Locations
- 1
- Primary Endpoint
- 1. Values of systolic and diastolic blood pressure (mmHg)
Study Overview
Brief Summary
Through a randomized, crossover, double-blind, placebo-controlled clinical trial, 20 bodybuilders will participate a acute-day trial with two intervention protocols: 1) placebo and 2) nitrate; in which will ingest beet juice with or without NO3 in its composition with a 7-day washout interval.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Supportive Care
- Masking
- Double (Participant, Investigator)
Eligibility Criteria
- Ages
- 18 Years to 45 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Anabolic steroid use in the past or actually;
- •Participation at least one bodybuilding competition;
Exclusion Criteria
- •Previous history of acute myocardial infarction and/or stroke;
- •Allergy or intolerance to nitrate, gluten, or milk;
- •Medications (proton pump inhibitors, beta-blockers, calcium channels antagonists).
Arms & Interventions
Placebo (Beetroot juice without NO3)
Placebo Comparator
Acute ingestion of beetroot juice rich depleted in NO3.
Intervention: Beetroot juice depleted in nitrate (Dietary Supplement)
Experimental (Beetroot juice NO3)
Experimental
Acute ingestion of beetroot juice rich in NO3 (800mg).
Intervention: Beetroot juice rich in nitrate (Dietary Supplement)
Outcomes
Primary Outcomes
1. Values of systolic and diastolic blood pressure (mmHg)
Time Frame: up to 2 years
Secondary Outcomes
- Plasmatic concentrations of nitrate and nitrite (mmol/L)(up to 2 years)
- Values of heart rate variability (ms)(up to 2 years)
- Values of heart rate (beats per minute)(up to 2 years)
- Values of hand grip strength (kgF)(up to 2 years)
- Plasmatic concentrations of nitrate and nitrite (mmol/L)(up to 2 years)
- Values of heart rate variability (ms)(up to 2 years)
- Values of heart rate (beats per minute)(up to 2 years)
- Macrovascular function (Flow mediated dilatation%)(up to 2 years)
- Values of hand grip strength (kgF)(up to 2 years)
Investigators
Cicero Jonas R Benjamim
Principal investigator
University of Sao Paulo
Study Sites (1)
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