eural correlates of suicidal behaviour: a longitudinal study

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 94

Inclusion Criteria

All participants (N=94)
- 18 - 60 years of age
- Written informed consent
Suicide attempt patients (N=46)
- Had a recent suicide attempt as judged by a psychiatrist (not more than six
months ago at moment of signing the informed consent)
Patient and Healthy controls (N=48)
- Matched to suicide attempt patients on age, sex, education, and handedness
- Never attempted suicide
Patient controls (N=24)
- Matched to suicide attempt patients on psychopathology
Healhty Controles (N=24)
- No current suicidal ideation defined by a BSS=0

Exclusion Criteria

All participants:
- Presence of a neurological disorder
- A suicide attempt in light of auto-euthanasia in presence of a terminal
somatic illness or
primarily caused by a psychotic delusion or hallucination
- Visual or hearing problems that cannot be corrected
- Insufficient knowledge of the Dutch language
- Not able to undergo 3 Tesla MRI scanning, these criteria include: (suspected)
pregnancy, claustrophobia, MR incompatible implants or objects in the body
(such as ear prostheses or other metal implants, operating clips or metal
particles in the eye), tattoos containing pigments that form a safety risk, the
refusal to be informed (by notifying the participants physician) of structural
abnormalities that could be detected during the experiment. , For Healthy
controls
- A past or current psychiatric disorder

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is brain activation/connectivity measured with<br /><br>functional magnetic resonance imaging (fMRI) during different types of<br /><br>emotional processing tasks and resting state. For the second objective, the<br /><br>main study endpoint will be the association between brain activation at first<br /><br>measurement and suicidal ideation/attempts at follow-up. For the third<br /><br>objective, the main endpoint will be change in brain activation at follow-up<br /><br>(second MRI scan) as compared to the first measurement.</p><br>

Secondary Outcome Measures