Endogenous steroid suppression in children and adolescents with nephrotic syndrome treated with steroids
Not Applicable
- Conditions
- Health Condition 1: E273- Drug-induced adrenocortical insufficiency
- Registration Number
- CTRI/2021/06/034046
- Lead Sponsor
- Maulana Azad Medical College and associated Lok Nayak Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Children and adolescents with steroid sensitive or steroid resistant nephrotic syndrome in the age group of 1-18 years, presently in remission (partial or complete) and
1. Who received daily prednisolone in any dosage for >= 2 weeks in the last 1 year and they are now off steroids or
2. Are presently receiving low dose alternate day prednisolone therapy ( <1 mg/kg/day) for atleast 8 weeks.
Exclusion Criteria
1.Children with nephrotic syndrome who received daily corticosteroid therapy in any dosages in the last 8 weeks.
2.Children with nephrotic syndrome having serious bacterial infections like pneumonia, cellulitis, sepsis, meningitis etc or are hospitalised for any reason.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Proportion of patients having adrenocortical insufficiency defined as serum cortisol 18 ug/dL by a low dose ACTH stimulation test. <br/ ><br>Timepoint: From OPD visit to individual patient samples will be analysed within five days. <br/ ><br>Thesis will be done in a year for the suggested sample size.
- Secondary Outcome Measures
Name Time Method Disease type, duration, cumulative steroid doses, correlation of steroid doses to baseline and stimulated serum cortisol values. <br/ ><br>Timepoint: From OPD visit to individual patient samples will be analysed within five days. <br/ ><br>Thesis will be done in a year for the suggested sample size.