Autonomic dysfunction in children and adolescents treated for hypothyroidism.
Not Applicable
- Conditions
- Health Condition 1: E031- Congenital hypothyroidism withoutgoiter
- Registration Number
- CTRI/2024/07/071017
- Lead Sponsor
- Maulana Azad Medical College
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Case: Children of age group 8- 18 years with primary hypothyroidism maintaining euthyroid status on L-thyroxine therapy for at least 6 months.
Controls: Age and gender matched apparently healthy children who are euthyroid of age group 8-18 years.
Exclusion Criteria
1. Undergoing structured physical activity regime over last 3 months.
2. Fever or systemic illness requiring hospitalization in preceding 4 weeks.
3. Previously diagnosed hypertension, renal disease or cardiovascular disease.
4. Any other associated endocrinal disorder like diabetes, adrenal disorders.
5. On any drug which might affect heart rate like beta blockers/ agonists/ calcium channel blockers.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Mean difference in heart rate variability of cases and controls. <br/ ><br>Timepoint: Baseline <br/ ><br>
- Secondary Outcome Measures
Name Time Method Mean difference in beat-to-beat variability in cases and controls. <br/ ><br>Association of sleep/wake cycle with Continuous Ambulatory Blood Pressure Monitoring in cases. <br/ ><br>Proportion of cases with abnormal Continuous Ambulatory Blood Pressure records. <br/ ><br>Correlation of Heart Rate Variability, mean Systolic Blood Pressure and Diastolic Blood Pressure with fT3, fT4 and TSH levels and disease duration.Timepoint: Baseline