Follow-up of cognition and cerebral hemodynamics in older adults with normal cognitive function and older adults with Mild Cognitive Impairment

Completed

Conditions: cognitive impairment
cerebrovascular dysfunction
10007963
10009841

Registration Number: NL-OMON48116

Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary: Trial ended prematurely

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 46

Inclusion Criteria

- Participated in one of our previous two studies (NL19014.091.07 or
NL54544.091.15);
- Informed consent;
- Adequate visual and auditory acuity to allow neuropsychological testing;
- Caregiver/informant available (applicable to cognitively impaired patients).

Exclusion Criteria

- Participants currently enrolled in any investigational drug study.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The change in cerebrovascular and cognitive function between the<br /><br>post-intervention measurements from the previous studies and the measurements<br /><br>from this follow-up study. Cognitive function will be assessed by comprehensive<br /><br>neuropsychological testing involving the tests listed in the protocol of the<br /><br>study in which each individual participated in (either NL54544.091.15 or<br /><br>NL19014.091.07). Cerebrovascular function measures will consist of cerebral<br /><br>autoregulation and cerebral vasomotor reactivity.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The (change in) physical fitness will be assessed using a submaximal<br /><br>incremental cycling test, hand grip strength test, 30 second chair stand test,<br /><br>and a physical activity questionnaire (LAPAQ).<br /><br>Other study parameters include clinical data on progression of cognitive<br /><br>impairment (new onset of MCI, changes in severity of MCI, progression to<br /><br>Alzheimer*s disease or dementia) or development of other diseases or comorbid<br /><br>conditions.</p><br>