Temporal course of impaired cerebral hemodynamics in patients with preeclampsia.

• Conditions: O14.9; Pre-eclampsia, unspecified

• Registration Number: DRKS00005674
• Lead Sponsor: eurozentrum, Abteilung für Neurologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2014-01-24
• Study Completion: 2015-09-13
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 70

Inclusion Criteria

1. Women within the first week post partum a) with preeclampsia b) without preeclampsia in this or a preceding pregnancy. 2. age 18 to 45 years. 3. Written informed consent.

Exclusion Criteria

1. High-grade stenosis of cerebral arteries. 2. History of stroke, TIA, brain operation, brain tumor. 3. No ultrasound window for transtemporal ultrasound. 4. Epilepsy.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Parameters of cerebral hemodynamics will be obtained in a transtemporal dopplersonographic evaluation of A. cerebri media and A. cerebri posterior.<br>Part A: Cerebral autoregulation (phase or gain) 6 months post partum.<br>Part B: Neurovascular coupling (resting flow velocity, overshoot flow velocity, steady-state flow velocity) 6 months post partum.

Secondary Outcome Measures

Name	Time	Method
Cardiovascular risk factors (arterial hypertension, diabetes mellitus, increased BMI). Clinical data will be inquired by means of a questionnaire.<br>Parameters of cerebral hemodynamics will be obtained in a transtemporal dopplersonographic evaluation of A. cerebri media and A. cerebri posterior.<br>Part A: Cerebral autoregulation (phase or gain) 2 years post partum.<br>Part B: Neurovascular coupling (resting flow velocity, overshoot flow velocity, steady-state flow velocity) 2 years post partum.