JPRN-UMIN000031866
Completed
未知
An exploratory study to identify biomarkers of resistance to chemotherapy in multiple myeloma - biomarker study in MM
The Institute of Medical Science, The University of Tokyo0 sites14 target enrollmentMarch 23, 2018
ConditionsMultiple Myeloma
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Multiple Myeloma
- Sponsor
- The Institute of Medical Science, The University of Tokyo
- Enrollment
- 14
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
Results: We identified several driver mutations by combined analysis of next-generation sequencing and existing databases of candidate oncogenes. Furthermore, relapse was detected more sensitively by monitoring the circulating cfDNA with these driver mutations than by conventional serum free-light chain examination. Conclusion: These results suggest the potential utility of cfDNA in the PB plasma of patients as a relevant early biomarker for MM relapse.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •Patients who are found to be inappropriate for this trial as judged by the principal investigator or the sub\-investigator
Outcomes
Primary Outcomes
Not specified
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