EUCTR2013-000189-12-NL
Active, not recruiting
Not Applicable
Effects of the selective mineralocorticoid receptor antagonist eplerenone on extracellular formation of adenosine - eplerenone and adenosine
niversity Medical Centre Nijmegen0 sitesMarch 8, 2013
Conditionshealthy volunteersTherapeutic area: Body processes [G] - Circulatory and Respiratory Physiological Phenomena [G09]
DrugsInspra
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- healthy volunteers
- Sponsor
- niversity Medical Centre Nijmegen
- Status
- Active, not recruiting
- Last Updated
- 13 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •male sex, age 18\-40 years, healthy, written informed consent
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1\.2 Adults (18\-64 years) yes
- •F.1\.2\.1 Number of subjects for this age range 14
- •F.1\.3 Elderly (\>\=65 years) no
- •F.1\.3\.1 Number of subjects for this age range
Exclusion Criteria
- •potassium \>4\.8 mmol/L, smoking, hypertension (SBP \>140 or DBP \>90 mmHg), hypotension (SBP \<100 or DBP \<60 mmHg), diabetes mellitus (fasting glucose \>7\.0 mmol/L or random \>11\.0 mmol/L), history of any cardiovascular disease, angina pectoris, history of COPD or asthma, alcohol and/or drug abuse, concomitant use of medication, renal dysfunction (MDRD \<60 mL/min), liver enzyme abnormalities (ALAT \>twice upper limit), fasting total cholesterol \>6 mmol/L, 2nd/3rd degree AV block on electrocardiography. During the study a serum potassium of \>5\.2 mmol/L is an exclusion criterium.
Outcomes
Primary Outcomes
Not specified
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